中国药理学通报2001，Vol.17Issue(1)：96-98,3.
单甘酯对实验性血栓形成的影响
Effect of glycol mannate sulfate on experimental thrombosis
焦波 1程艳娜 1朱媛媛 2纪建波 1张世玲 1袁玮3
作者信息
- 1. 山东大学药学院药理学教研室
- 2. 齐鲁医院血研室
- 3. 医学院药理教研室,
- 折叠
摘要
Abstract
AIM To investigate the antithrobosis effects of glycol mannate sulfate(GMS). METHODS Vein thrombus was formed in rat by ligating postcava. Thrombus formation in vitro was observed by Chandlers method. Clotting indexes were measure by ACL200 congulation system. RESULTS GMS dosage of 20、40 mg*kg-1 could inhibit the vein thrombus formation in rats (P<0.01). GMS could inhibit the thrombosis in rabbit, in vivo, and the inhibitory action was enhanced along with the increase of dosage. The CT,TT,CT,APTT,RT and PT were prolonged, and the fibrinogen and the activity of Ⅱ and Ⅱa were decreased. The activity of ATⅢ was enhenced. CONCLUSION GMS has antithrombotic effect and the mechanism may be related to the anticongulat effect.关键词
单甘酯/血栓形成/抗凝作用分类
医药卫生引用本文复制引用
焦波,程艳娜,朱媛媛,纪建波,张世玲,袁玮..单甘酯对实验性血栓形成的影响[J].中国药理学通报,2001,17(1):96-98,3.
