中华医学杂志（英文版）2003，Vol.116Issue(7)：976-980,5.
Pathological study on severe acute respiratory syndrome
Pathological study on severe acute respiratory syndrome
郎振为 1张立洁 1张世杰 1孟忻 1李俊强 1宋晨朝 1孙琳 1周育森1
作者信息
- 1. Department of Pathology, Beijing Youan Hospital, Capital University of Medical Sciences, Beijing 100054, China
- 折叠
摘要
Abstract
Objective To study the pathological characteristics of severe acute respiratory syndrome (SARS) and its relationship to clinical manifestation. Methods Tissue specimens from 3 autopsies of probable SARS cases were studied by microscope, and the clinical data was reviewed.Results The typical pathological changes of lungs were diffuse hemorrhaging on the surface. A combination of serous, fibrinous and hemorrhagic inflammation was seen in most of the pulmonary alveoli with the engorgement of capillaries and detection of micro-thrombosis in some of these capillaries. Pulmonary alveoli thickened with interstitial mononuclear inflammatory infiltrates, suffered diffuse alveolar damage, experienced desquamation of pneumocytes and had hyaline-membrane formation, fibrinoid materials, and erythrocytes in alveolar spaces. There were thromboembolisms in some bronchial arteries. Furthermore, hemorrhagic necrosis was also evident in lymph nodes and spleen with the attenuation of lymphocytes. Other atypical pathological changes, such as hydropic degeneration, fatty degeneration, interstitial cell proliferation and lesions having existed before hospitalization were observed in the liver, heart, kidney and pancreas.Conclusion Severe damage to the pulmonary and immunological systems is responsible for the clinical features of SARS and may lead to the death of patients.关键词
lung diseases/severe acute respiratory syndrome/communicable diseases/autopsyKey words
lung diseases/severe acute respiratory syndrome/communicable diseases/autopsy分类
医药卫生引用本文复制引用
郎振为,张立洁,张世杰,孟忻,李俊强,宋晨朝,孙琳,周育森..Pathological study on severe acute respiratory syndrome[J].中华医学杂志（英文版）,2003,116(7):976-980,5.
