中华医学杂志（英文版）2001，Vol.114Issue(9)：976-982,7.
动脉去内皮损伤后降脂药物对生长因子作用影响的分子机制
Molecular basis for the effect of lipid lowering drugs on growth factors after de-endothelialization
周漪 1刘欣岩 1佘铭鹏1
作者信息
- 1. 中国医学科学院中国协和医科大学基础医学研究所病理室
- 折叠
摘要
Abstract
Objective To study the mechanism and effect of lipid lowering drugs in arresting the development of arterial restenosis after angioplasty.
Methods De-endothelialization injury of rabbit aortae, common iliac and femoral arteries using balloon angioplasty and the expression of growth factors such as platelet derived growth factor-B (PDGF-B), transforming growth factor β-1 (TGFβ-1), and fibroblast growth factos (bFGF) were investigated. Total serum cholesterol (TC) and triglycerides (TG) were analyzed during and after the treatment using either simvastatin combined with gemfibrozil or simvastatin alone for 6 weeks.
Results Serum total cholesterol and triglycerides were only slightly to moderately increased after high cholesterol ration intake lasting for 6 weeks in rabbits of two therapeutic groups (simvastatin plus gemfibrozil or only simvastatin). A positive correlation was found between TC and intimal/medial ratio (r=0.5873, P<0.05). PDGF-B detected by immuno-histochemistry and RT-PCR analysis showed that the release of PDGF-B was inhibited by simvastatin and gemfibrozil after de-endothelialization. RT-PCR analysis showed that TGFβ-1 was increased in the neointima in two treatment groups but no definite change was seen in the mRNA of bFGF in the smooth muscle cell (SMC) of the balloon-injured arteries even under lipid lowering drug treatment.
Conclusion In addition to the lipid lowering effect, both simvastatin and gemfibrozil also influence the release of PDGF-Band TGF-1 in the neointima after de-endothelialization.关键词
动脉损伤/再狭窄/降脂药物/细胞介质分类
医药卫生引用本文复制引用
周漪,刘欣岩,佘铭鹏..动脉去内皮损伤后降脂药物对生长因子作用影响的分子机制[J].中华医学杂志（英文版）,2001,114(9):976-982,7.
