现代康复2001，Vol.5Issue(5)：97-98,2.
哮喘豚鼠外周血淋巴细胞凋亡及白细胞介素一5和粒细胞/
巨噬细胞集落刺激因子mRNA表达的研究
Apoptosis and expression of mRNA Encoding IL - 5 and GM - CSF of peripheral lymphatic cell in asthmatic guinea pig
郭晓明 1郭爱云 1严绍增 1王长征 2钱桂生2
作者信息
- 1. 解放军第二五一医院,
- 2. 解放军第三军医大学新桥医院
- 折叠
摘要
Abstract
Objective Toinvestigate apoptosis and expression of mRNA encoding IL-5 and GM-CSF of peripheral lymphatic cell ofasthmatic guinea pig. Method 30 guinea pigs were equally aasigned to asthmatic or control group. tumel was used to determine the rate ofapoptosis and in situ hybridization(ISH) was used to examine the expression of mRNA encoking IL-5 and GM-CSF of perpheral lymphatic
cell. Result the rate of apoptosis in asthmatic group(3.50 ± 1.00% )was much lower than that in control group (6. 80 ± 1.50% ) (p ＜0. 01 ). the positive rates of expression of mena encoding IL - 5 and GM - CSF in asthmatic group(58.00 ±6.00%, 49. 00 ±4.00% ) were much
higher than that in control group(30. 00 ± 2. 00%, 24.00 ± 2. 00% ) . Conclusion The hyper-expression of mRNA encoding IL-5 and
GM - CSF in perpheral lymphatic cell may be related with the activation as well as the decrease of apoptosis of lymphatic cell, which inducedmore secretion of cytokine.关键词
哮喘/细胞凋亡/淋巴细胞/白细胞介素-5分类
医药卫生引用本文复制引用
郭晓明,郭爱云,严绍增,王长征,钱桂生..哮喘豚鼠外周血淋巴细胞凋亡及白细胞介素一5和粒细胞/
巨噬细胞集落刺激因子mRNA表达的研究[J].现代康复,2001,5(5):97-98,2.
