中国癌症防治杂志2009，Vol.1Issue(2)：98-100,3.
ESR1基因多态性与原发性肝癌发生的相关性研究
Study on the relationship between polymorphism of ESR1 gene and primary liver cancer
摘要
Abstract
Objective To study the association between polymorphism of ESR1 gene in primary liver cancer (PLC) in Fusui area of Guangxi.Methods 50 cases of PLC with Zhuang nationality, 50 cases of PLC with Han nationality, 37 cases from high risk population with Zhuang nationality, 37 cases from high risk population with Han nationality, 30 cases from normal population with Zhuang nationality and 30 cases from normal population with Han nationality were enrolled in this study.SNP locus rs 9340772 of ESR1 gene was selected as genetic marker.The genotypes and genetic mutation frequency of all the cases were detected by polymerase chain reaction combined with restriction fragment polymorphism method (PCR-RFLP).Results There was no mutation in SNP locus rs 9340772 of ESR1 in PLC group, the high risk population group and the normal population group.The expression of ESR1 showed no statistically significant difference among the three groups (P＞0.05).Conclusion Polymorphism SNP locus rs 9340772 of ESR1 gene is not associated with PLC.关键词
原发性肝癌/雌激素受体/基因多态性Key words
Primary liver cancer/Estrogen receptor/Gene polymorphism分类
医药卫生引用本文复制引用
楼建军,谢裕安,罗小玲,匡志鹏,杨志国,吴昊..ESR1基因多态性与原发性肝癌发生的相关性研究[J].中国癌症防治杂志,2009,1(2):98-100,3.基金项目
国家自然科学基金项目(NO 30660204) （NO 30660204）
