肿瘤防治研究2001，Vol.28Issue(2)：98-99,101,3.
胃良、恶性病变中p16蛋白表达的研究
To Study the Expression of p16 in Benign and Malignant Gastric Lesions
范开席 1王绍平 1唐基栋 1王哲海1
作者信息
- 1. 山东省肿瘤医院内二科 济南，250117
- 折叠
摘要
Abstract
Objective To study the expression of p16 suppressor gene inbenign and malignant gastric lesions and its correlation with occurrence and development of gastric cancer.Methods p16 was observed in 10 normal gastric tissue、35 benign lesions and 65 gastric cancer with LSAB immunohistochemical methods.Results The positive expression rate of p16 in the normal gastric tissue was 100%,the rate of benign lesions was 75%～87.5%,the rate of gastric cancer was 30.8%.The positive expression rate of p16 was higher in high and middle differentiation than low and small cell carcinoma (P<0.05),The positive expression of p16 was significantly correlated with TNM stage.Conclusion p16 may play some roles in the development of gastric cancer, the expression of p16 may assess the prognosis in gastric cancer.关键词
胃癌/免疫组织化学/p16基因/p16蛋白分类
医药卫生引用本文复制引用
范开席,王绍平,唐基栋,王哲海..胃良、恶性病变中p16蛋白表达的研究[J].肿瘤防治研究,2001,28(2):98-99,101,3.
