中国药理学通报2001，Vol.17Issue(1)：99-101,3.
甲基葡糖苷对豚鼠离体心房的正性肌力作用
Positive inotropic effect of methyl polyglycoside
on isolated guinea pig atria
罗学娅 1王桂林 2张莎莎2
作者信息
- 1. 大连大学医学院药理学教研室,
- 2. 内蒙古医学院药理学教研室,
- 折叠
摘要
Abstract
AIM To study the positive inotropic effect of methyl polyglycoside (Mpg) on isolated guinea pig atria and its mechanism. METHODS The effects of Mpg on contractility, beat rate of right atria, post-rest contraction and positive staircase phenomenon were observed in isolated guinea pig left and right atria. Na+-K+-ATPase activity of rat myocardial cell membrane was measured. RESULTS Mpg (0.01～3 mmol*L-1) produced a concentration-dependent increase in myocardial contractility of atria and decrease in beat rate of right atria. Mpg markedly enhanced the post-rest contraction and the positive staircase phenomenon induced by increasing stimulation frequency in left atria, and inhibited Na+-K+-ATPase activity of rat myocardial cell membrane. CONCLUSION The results suggest that Mpg can strengthen myocardial contractility of atria and decrease beat rate of right atria. Its positive inotropic effect may be related to inhibiting Na+-K+-ATPase activity of myocardial cell membrane, increasing the transmembrane influx of calcium and the amount of calcium released from intracellular stores.关键词
甲基葡糖苷/心房/正性肌力作用/Na+-K+-ATP酶/Ca2+分类
医药卫生引用本文复制引用
罗学娅,王桂林,张莎莎..甲基葡糖苷对豚鼠离体心房的正性肌力作用[J].中国药理学通报,2001,17(1):99-101,3.
