中华医学杂志（英文版）2007，Vol.120Issue(11)：996-999,4.
MicroRNA gene expression in malignant lymphoproliferative disorders
MicroRNA gene expression in malignant lymphoproliferative disorders
摘要
Abstract
Objective To review the recent studies about microRNAs and advances in malignant lymphoproliferative disorders.Data sources Published articles (2001-2006) about microRNAs and malignant iymphoproliferative disorders were selected using MEDLINE.Study selection After independent review by two observers, 43 of 421 originally identified articles were selected that specifically addressed the stated purpose.Results Two observers independently assessed studies using explicit methodological criteria for evaluating microRNAs in malignant lymphoproliferative disorders. Recent work has revealed a class of small noncoding RNA species,microRNAs, which affect various biological processes. MicroRNAs inhibit the expression of protein encoding genes at the posttranscriptional level in a variety of eukaryotic organisms. In this review, we focused on the biogenetic pathways of microRNAs (miR-15a, miR-16-1, miR-155, miR-17-92 cluster, miR-142) and discussed the implications for human malignant lymphoproliferative disorders.Conclusions microRNAs are involved in tumorigenesis and mediate gene regulation as a fundamental genetic program at the posttranscriptional level. Further study of microRNAs may lead to novel concepts in the diagnosis and treatment of malignant lymphoproliferative disorders.关键词
microRNA/lymphoproliferative disordersKey words
microRNA/lymphoproliferative disorders分类
医药卫生引用本文复制引用
XU Wei,LI Jian-yong..MicroRNA gene expression in malignant lymphoproliferative disorders[J].中华医学杂志（英文版）,2007,120(11):996-999,4.基金项目
This study was supported by the grant from the "135" Foundation of Jiangsu Province (No. RC2002044). （No. RC2002044）
