安徽农业科学2009，Vol.37Issue(21)：9999-10001,10214,4.
小鼠褪黑激素注射的毒理性研究
Study on the Toxicity of Melatonin Injected in the Belly Cavity of Mice
魏延贤 1何百花 2段秀梅3
作者信息
- 1. 青海省海北州门源县泉沟台兽医站,青海门源,810300
- 2. 青海省海北州门源县西滩乡畜牧兽医站,青海门源,810300
- 3. 德州学院农学系,山东德州,253023
- 折叠
摘要
Abstract
[Objective]The reference for the evaluation of the toxicity of melatonin in the belly cavity of mice was provided. [Method]The toxicity of melatonin in the belly cavity of mice was researched through the experiment in acute toxicity, sub-acute toxicity, micronucleus and distortion sperm. [Results]The experimental result indicated that the acute toxicity(LD50) was (255.910±41.188)mg/kg. In the sub-acute toxicity testing, the number of red blood cell and white blood cell was in normal range;the difference of lymphocyte, neutrophil, monocyte, eosinophil and basophil was cells was no significant with those of the CK;and there was no abnormal change in its anatomic observation and also the pathological change in all of tissue dissections. The experimental result from Ames, micronucleus and distortion sperm-testing showed that the melatonin injected in the belly cavity of mice did not result in the mutation effect and did not cause the distortion of mice chromosome and sperm. [Conclusion]The melatonin injected in the belly cavity of mice did not affect the hemogram, some biochemical parameters of blood and organization of mice and also the distortion of chromosome and sperm, and mutant induced of mice were found, however, it was speculated that it could cause the toxicity to mice nerve system.关键词
褪黑激素/腹腔注射/急性毒性/亚急性毒性Key words
Melatonin/Belly cavity injection/Acute toxicity/Sub-acute toxicity分类
农业科技引用本文复制引用
魏延贤,何百花,段秀梅..小鼠褪黑激素注射的毒理性研究[J].安徽农业科学,2009,37(21):9999-10001,10214,4.
