国际医药卫生导报2010，Vol.16Issue(5)：574-576,3.DOI:10.3760/cma.j.issn.1007-1245.2010.05.025
t-PSA与c-PSA对前列腺癌和良性前列腺增生的鉴别诊断意义
The using Value of t-PSA and c-PSA to differential diagnosis the prostate neoplasms and BPH
陈平 1刘健 1姚艺雄 1蔡健梅 1梁梅芳1
作者信息
摘要
Abstract
Objective To research the using value of t-PSA and c-PSA to differential diagnosis the prostate neoplasms and BPH. Methods The level of t-PSA and c-PSA were measured in the 89 cases of PCa, 111 cases of BPH by Chemiluminescence analysis. Results The level of t-PSA was (3.6±2.4) ng/ml(BPH) and (15.2±16.2) ng/ml(PCa) (P<0.01). The false negative was 50.6% (cutoff= 10ng/ml) and 27.0% (cutoff =2.5ng/ml). The level of c-PSA was (0.08±0.06) ng/ml(BPH) and (28.9±37.6) ng/ml(PCa) (P<0.01), The false negative was 20.2% (cutoff =2.5ng/ml). When the cutoff of t-PSA was 2.5 ng/ml, to combine the c-PSA would raise the positive up to 69.7 %. Conclusion When the cutoff of t-PSA was 10.0 ng/ml, the c-PSA was significantly higher than t-PSA. We suggest adjust the cutoff of t-PSA to 2.5 ng/ml, and to combine the c-PSA would significant raise the Sensitivity and Specificity by diagnosis the prostate neoplasms.关键词
总前列腺特异性抗原(t-PSA)/复合前列腺特异性抗原(c-PSA)/前列腺癌(PCa)/前列腺增生(BPH)Key words
Total prostate-specific antigen(t-PSA)/Complexed prostate-specific antigen(c-PSA)/Prostatic neoplasms (PCa)/Benign prostatic hyperplasia(BPH)引用本文复制引用
陈平,刘健,姚艺雄,蔡健梅,梁梅芳..t-PSA与c-PSA对前列腺癌和良性前列腺增生的鉴别诊断意义[J].国际医药卫生导报,2010,16(5):574-576,3.
