首页|期刊导航|中华医学杂志（英文版）|Influence of insulin resistance on long-term outcomes in patients with coronary artery disease after sirolimus-eluting stent implantation
中华医学杂志（英文版）2010，Vol.123Issue(6)：651-657,7.DOI:10.3760/cma.j.issn.0366-6999.2010.06.003
Influence of insulin resistance on long-term outcomes in patients with coronary artery disease after sirolimus-eluting stent implantation
Influence of insulin resistance on long-term outcomes in patients with coronary artery disease after sirolimus-eluting stent implantation
摘要
Abstract
Background Insulin resistance(IR)is significantly associated with coronary artery disease and cardiovascular events in patients with or without type 2 diabetes mellitus.This study aimed to evaluate the influence of IR on long-term outcomes of patients undergoing percutaneous coronary intervention(PCI)with sirolimus-eluting stent(SES)implantation.Methods A total of 467 consecutive patients undergoing SES-based PCI were divided into lR group(n=104)and non-IR group(n=363).The patients were followed up for one year.The rate of major adverse cardiac events(MACEs) including death, non-fatal myocardial infarction and recurrent angina pectoris was compared by the log-rank test,and the independent risk factors were identified by the Cox regression analysis.Results MACEs occurred more frequently,and cumulative survival rate was lower in the IR group than in the non-IR group during the follow-up (all P<0.05).IR was an independent risk factor for the occurrence of cardiac death and non-fatal myocardial infarction(OR=2176,95% CI=1.35-5.47,P=0.034).Old age,diabetes,and multi-vessel disease were determinants for recurrent angina pectoris after PCI(P<0.05).Subgroup analysis revealed that IR(OR=3.35,95% CI=1.07-13.59,P=0.013)and multi-vessel disease(OR=2.19,95%CI=1.01-5.14,P=0.044)were independent risk predictors for recurrent angina pectoris in patients with diabetes after PCI.Conclusions IR is associated with reduced MACE-free survival and remains an independent predictor for recurrent angina pectoris after PCI with SES implantation.关键词
insulin resistance/coronary artery disease/sirolimus-eluting stent/long-term prognosispatientsKey words
insulin resistance/coronary artery disease/sirolimus-eluting stent/long-term prognosispatients引用本文复制引用
ZHAO Liang-ping,L(U) An-kang,SHEN Wei-feng,LIU Hai-feng,MA Xiao-ye,FAN Xiao-ming,ZHANG Qi..Influence of insulin resistance on long-term outcomes in patients with coronary artery disease after sirolimus-eluting stent implantation[J].中华医学杂志（英文版）,2010,123(6):651-657,7.基金项目
This study was supported by a grant from the Shanghai Shenkang Hospital Development Foundation (No. SHDC12007318). （No. SHDC12007318）
