首页|期刊导航|中华医学杂志（英文版）|High-density lipoprotein associated factors apoA-I and serum amyloid A in Chinese non-diabetic patients with coronary heart disease
中华医学杂志（英文版）2010，Vol.123Issue(6)：658-663,6.DOI:10.3760/cma.j.issn.0366-6999.2010.06.004
High-density lipoprotein associated factors apoA-I and serum amyloid A in Chinese non-diabetic patients with coronary heart disease
High-density lipoprotein associated factors apoA-I and serum amyloid A in Chinese non-diabetic patients with coronary heart disease
摘要
Abstract
Background High-density lipoprotein cholesterol(HDL-C)levels are a strong,independent inverse predictor of coronary heart disease (CHD).In this cross-sectional study we investigated the interrelationships between HDL-C and HDL relaled factors apolipoprotein A-I(apoA-I)and serum amyloid A(SAA)and the presence and extent of CHD in a population of Chinese patients with CHD. Methods Two hundred and twenty-four consecutive patients took part in this study.Demographic data were obtained from hospital records.Serum chemical concentrations were measured by standard laboratory methods.Reaults The concentrations of high-sensitive C-reactive protein(hsCRP)(median:1.85 mg/L)and SAP,(median:9.40 mg/L)were significantly higher in the CHD group(P<0.05),while concentrations of HDL-C(0.03±0.25)mmol/L)and apoA-I((604.59±1 05.79)mmol/L)were significantly lower than those in the non-CHD group(P<0.05).The concentrations of apoA-l decreased with the increase in vascular damage.but the difference did not reach statistical significance.However, the concentrations of hsCRP and SAA increased with the increase in vascular damage.The unadjusted odd ratios(ORs)(CI) for apoA-I and SAA of the presence of CHD were 0.093(0.990-0.997)(P=0.00)and 2.571(1.029-6.424)(P<0.05),respectively.The association between elevated SAA and the presence of CHD was lost after adjusting for lipid status parameter concentrations.The associations between apoA-I.SAA and the extent of CHD remained strong,regardless of confounding variables.Conclusions Increased concentrations of SAA represent the inflammatory marker of the extent of coronary stenosis in patients with CHD.In contrast to SAA, the level of apoA-I was also associated with the presence of CHD, indicating that apoA-I was not only a marker of CHD presence but also a quantitative indicator of CHD extent.In short.determining the change apolipoprotein content within HDL particle is a more accurate and effective method to evaluate the impact of HDL on CHD.关键词
high-density lipoprotein/apolipoproteinA-I/serum amyloidA/coronary heart diseaseKey words
high-density lipoprotein/apolipoproteinA-I/serum amyloidA/coronary heart disease引用本文复制引用
CHEN Guo-liang,LIU Li-wei,XIE Shuang,LIU Hong,LIU Yu-qing ,LI Yi-shi..High-density lipoprotein associated factors apoA-I and serum amyloid A in Chinese non-diabetic patients with coronary heart disease [J].中华医学杂志（英文版）,2010,123(6):658-663,6.基金项目
This study was supported by a grant from the 11th Five-Year Project (No. 2008ZX09312-018). （No. 2008ZX09312-018）
