摘要
Abstract
Recently study suggested that dementia related to cerebral cortex and subcritical degeneration of nerve cells.But precise etiology has been inconclusive.Lots of new drugs have been developed and developing,such as cholinesterase inhibitors(CHEI),Ml agonists,prevent β-amyloid protein(β A4)deposition of drugs,inhibit γ-secretion of enzyme drugs,free radical scavenging drugs,calcium antagonists,hormones drugs,traditional Chinese Medicine research has also made clear progress.Some natural medicine active ingredients,such as Huperzine A,Ginkgo biloba extract,Osthol,Sal and so has the expansion of cerebral blood vessels and increase cerebral blood flow,scavenging free radicals,immune regulation,and through inhibition of brain liner alkaline esterase activity,increased excitatory.neurotransmitter-acetylcholine content,improve the symptoms of Alzheimer's disease patients.As the free radical theory and the rerebellum are closely mimed to in-depth study of vascular cell factor in the further and development of genetic engineering and the emergence of classes of cholinergic drugs,the study of AD drugs will further expand.关键词
胆碱酯酶抑制剂/M1受体激动药/防止β-淀粉蛋白(βA4)沉积药/γ-分泌酶抑制剂/自南基清除/钙拮抗剂/激素药物Key words
CHEI/M1 agonists/Prevent β-amyloid protein(β A4)deposition drugs/Inhibitγ-secretion of enzyme free radical scavenging drugs/Calcium antagonists/Hormonesd
