中华医学杂志（英文版）2010，Vol.123Issue(7)：954-960,7.DOI:10.3760/cma.j.issn.0366-6999.2010.07.034
Leukemia stem cells in drug resistance and metastasis
Leukemia stem cells in drug resistance and metastasis
摘要
Abstract
Objective To review the central role of leukemia stem cells (LSCs) in drug resistance and metastasis, aiming to provide key insights into leukemogenic pathology and developing novel therapeutic strategies against the relapse of leukemia.Data sources The data used in this review were obtained mainly from the studies reported in PubMed using the key terms "tumor-initiating cells", "leukemia stem cells", "drug resistance" and "metastasis".Study selection Relevant articles on studies of leukemia stem cells were selected.Results Increasing numbers of studies have suggested the importance of cancer stem cells (CSCs) in the initiation and maintenance of cancer, especially in leukemia. This review has summarized the origin, characteristics, isolation and identification of LSCs. It highlights the crucial role of LSCs in drug resistance and metastasis of leukemia by illustrating possible mechanisms and aims to provide novel therapeutic strategies for LSCs-targeted treatment.Conclusion LSCs play a crucial role in drug resistance and metastasis of leukemia and new promising LSCs-targeted therapies warrant investigation in both experimental models and clinical practice.关键词
cancer stem cells/leukemia/drug resistance/metastasisKey words
cancer stem cells/leukemia/drug resistance/metastasis引用本文复制引用
DENG Chao-hua ,ZHANG Qiu-ping..Leukemia stem cells in drug resistance and metastasis[J].中华医学杂志（英文版）,2010,123(7):954-960,7.基金项目
This study was supported by the grants from the National Natural Science Foundation of China (No. 30570780 and No. 30971280), the National Ministry of Doctoral Fund (No. 200804860039), and the Innovation Project of National Undergraduate (No. 091048649). （No. 30570780 and No. 30971280）
