国际医药卫生导报2010，Vol.16Issue(19)：2324-2326,3.DOI:10.3760/cma.j.issn.1007-1245.2010.19.004
偏头痛患者外周血一氧化氮和内皮素含量变化的探讨
Changes in peripheral levels of nitric oxide and endothelin-1 in migraine patients
摘要
Abstract
Objective To explore the changes in peripheral levels of nitric oxide (NO) and endothelin-1 (ET-1) in migraine patients during attack and interictal period. Methods Serum levels of NO and ET-1 were detected by spectrophotometry and radioimmunoassay in 45 patients with migraine attack and 41 patients in the interictal period. The results were compared with those from healthy subjects.Results Levels of NO and ET-1 were significantly higher in the patients with attack than in the healthy subjects. NO levels decreased significantly in the interictal period, being close to those from the healthy subjects, while ET-1 levels remained at a higher level, which had no significant difference as compared with those in the interictal period, but significantly different from the normal group. Conclusions Peripheral levels of NO and ET-1 levels obviously elevate in migraine attack; NO levels return to nearly normal interictal periods while ET-1 levels remained at a higher level. Increased levels of NO and ET-1 and disbalance between them are an important cause of migraine attack.关键词
偏头痛/发作期/间歇期/NO/ET-1Key words
Migraine/Attack/Interictal period/Nitric oxide/Endothelin-1引用本文复制引用
曾昭龙,许绍强,胡湘蜀,陈文明,卢健军..偏头痛患者外周血一氧化氮和内皮素含量变化的探讨[J].国际医药卫生导报,2010,16(19):2324-2326,3.基金项目
广东省中医药管理局科研课题(2008399) （2008399）
