中华医学杂志（英文版）2010，Vol.123Issue(17)：2379-2383,5.DOI:10.3760/cma.j.issn.0366-6999.2010.17.018
Feasibility of vertebral internal fixation using deer and sheep as animal models
Feasibility of vertebral internal fixation using deer and sheep as animal models
LIU Guo-min 1LI You-qiong 2XU Chuan-jie 3ZHU Xiao-min 4LIU Yi1
作者信息
- 1. Department of Orthopedics,Second Hospital of Jilin University, Changchun, Jilin 130041,China
- 2. Basic Medical Department of Jilin University, Changchun, Jilin 130041, China
- 3. Department of Pathology,Second Hospital of Jilin University, Changchun, Jilin 130041,China
- 4. Department of Gastroenterology,Second Hospital of Jilin University, Changchun, Jilin 130041,China
- 折叠
摘要
Abstract
Backgroud Studies on new vertebral internal fixations of animals are very important prior to clinical application. This study aimed to determine the feasibility of vertebral internal fixation on morphologic and biomechanical properties using deer and sheep as animal models and comparing to human data.Methods Thirty sets of fresh Sika deer lumbar, 30 sets of fresh sheep lumbar, and 20 sets of fresh lumbar from male cadavers were used. We examined the morphology of the centra and pedicles of the three groups, and determined the cancellous bone density and biomechanical properties in all groups.Results There were marked differences in all parameters measured between the different species. The sizes of the upper, middle, and lower transverse diameter were largest in the human, followed by the deer, then the sheep. The index of centrum transverse diameters and sagittal diameters were less than 0.8 (a triangle), and the deer was more similar to the human. The heights of the right vertebral pedicles and the anterior disc heights (IDH) were largest in the human, followed by the deer, then the sheep. The apparent density, elastic modulus, and ultimate load were largest in the sheep, followed by the deer, then the human. The range of motion (ROM) of functional lumbar units (FLUs) with a combined flexion-extension moment was largest in the human, followed by the deer then the sheep. Conclusions The deer lumbar is more similar to that of human in anatomical form and biomechanics than the sheep lumbar. As such, deer is more appropriate as an animal model for use in vertebral internal fixation studies.关键词
deer/sheep/lumbar/morphology/bone density/biomechanicsKey words
deer/sheep/lumbar/morphology/bone density/biomechanics引用本文复制引用
LIU Guo-min,LI You-qiong,XU Chuan-jie,ZHU Xiao-min,LIU Yi..Feasibility of vertebral internal fixation using deer and sheep as animal models [J].中华医学杂志（英文版）,2010,123(17):2379-2383,5.
