国际医药卫生导报2010，Vol.16Issue(15)：1819-1820,2.DOI:10.3760/cma.j.issn.1007-1245.2010.15.010
凋亡基因Bcl-2/Bax与高脂饮食诱导大鼠胰岛细胞凋亡的关系研究
Relation of apoptosis-related genes with apoptosis of rat pancreatic islet cells due to high fat diet
谢彬 1劳干诚 1徐刚 1冉建民1
作者信息
- 1. 510220,广州暨南大学附属红十字会医院内分泌科
- 折叠
摘要
Abstract
Objective To investigate the relation of apoptosis-related genes with apoptosis of rat pancreatic islet cells due to high fat diet. Methods Apoptotie cells were identified by TUNEL assay, mRNA levels of bcl-2 and Bax were evaluated by immunohistochemical staining. Results High level of fat diet increased the proportion of the apoptotic cell. In the process of apoptosis, mRNA level of Bax increased significantly, while bcl-2mRNA expression decreased. Conclusions High fat diet may induce and exacer-bate diabetes through inducing apoptosis of the islet cells. The change in the ratio of bel-2/Bax mRNA expression may play an important role in apoptosis.关键词
高脂饮食/胰岛细胞凋亡/凋亡基因Key words
High fat diet/Apoptosis/Apoptosis-related genes引用本文复制引用
谢彬,劳干诚,徐刚,冉建民..凋亡基因Bcl-2/Bax与高脂饮食诱导大鼠胰岛细胞凋亡的关系研究[J].国际医药卫生导报,2010,16(15):1819-1820,2.
