国际医药卫生导报2010，Vol.16Issue(18)：2229-2231,3.DOI:10.3760/cma.j.issn.1007-1245.2010.18.013
新生儿脐血地贫筛查和葡萄糖-6-磷酸脱氢酶缺乏的分析
Prenatal screening of thalassemia in 7210 samples of neonatal cord blood and G6PD deficiency
余小燕 1余相 1张丽科1
作者信息
- 1. 516001,惠州市中心人民医院产前诊断中心
- 折叠
摘要
Abstract
Objective To explore the incidence of newborn hemoglobinopathy and erythrocyte enzyme disorders after regular prenatal visits and genetic consulting. Methods The band on hemoglobin electrophoresis and the G6PD level were detected in 7210 samples of umbilical cord blood by hemoglobin electrophoresis and G6PD ratio method. Results Of 7210 samples,the detection rate of G6PD deficiency was 4.38％. The detected rates of α -thalassemia with a/a mutation and standard α-thalassemia were 2.50％and 5.89％. The incidence of the three disorders in 2009 was decreased by 0.18％,0.08％,and 0.44％,as compared with 2008. Conclusions The probability of the incidence of the disorders reduces in the confirmed low-risk neonates after regular prenatal visits and consulting,as compared with the predictive probability. Prenatal visits and genetic consulting play an important role in preventing the birth rate of neonates with severe thalassemia.关键词
血红蛋白电泳/G6PD/脐血/产前检查/遗传咨询Key words
Hemoglobin electrophoresis/Glucose-6-phosphate dehydrogenase/Umbilical cord blood/Prenatal visits/Genetic consulting引用本文复制引用
余小燕,余相,张丽科..新生儿脐血地贫筛查和葡萄糖-6-磷酸脱氢酶缺乏的分析[J].国际医药卫生导报,2010,16(18):2229-2231,3.
