国际医药卫生导报2010，Vol.16Issue(17)：2122-2124,3.DOI:10.3760/cma.j.issn.1007-1245.2010.17.021
乌司他丁和糖皮质激素在慢性阻塞性肺疾病并呼吸衰竭中的对比研究
Ulinastatin versus glucocorticoids in the treatment of COPD with acute respiratory failure
刘俊 1刘远波2
作者信息
- 1. 543002,梧州市红十字会医院内科重症监护病房
- 2. 543002,梧州市第三人民医院
- 折叠
摘要
Abstract
Objective To compare the efficacy of ulinastatin versus that of glucocorticoids for chronic obstructive pulmonary disease (COPD) with acute respiratory failure. Methods 68 patients with COPD and acute respiratory failure were randomly divided into ulinaatatin group and glucocorticoids group.The effect of these two different therapies on respiratory mechanics was compared. The outcomes and the incidence ratio of complications were analyzed. Results The airway peak pressure and the plateau pressure were obviously reduced, especially in glucocorticoids group, and the difference was significant on day 2 as compared with ulinastatin group; but they did not differ significantly on day 3. There were no significant differences in the success rate of ventilator removal (in 10 days), the incidence of hyperglycemia, and the mortality rate. The incidences of upper gastrointestinal bleeding and worsened infection were hgiher in glucocorticoids group than in ulinastatin 8roup.Conclusions Ulinastatin is effective in the treatment of COPD with acute respiratory failure and has fewer complications.关键词
乌司他丁/糖皮质激素/慢性阻塞性肺疾病Key words
Ulinastatin/Glucocorticoids/COPD引用本文复制引用
刘俊,刘远波..乌司他丁和糖皮质激素在慢性阻塞性肺疾病并呼吸衰竭中的对比研究[J].国际医药卫生导报,2010,16(17):2122-2124,3.
