国际医药卫生导报2010，Vol.16Issue(14)：1690-1692,3.DOI:10.3760/cma.j.issn.1007-1245.2010.14.008
环磷酰胺对长爪沙鼠血常规的影响
Effect of cyclophosphamide on routine blood tests for Meriones unguiculatus
梁成结 1钟欢妹 2梁坤 3杨僖 3许楚 3何秉嘉3
作者信息
- 1. 510182,广州医学院实验动物研究中心
- 2. 511300,增城市人民医院检验科
- 3. 510182,广州医学院
- 折叠
摘要
Abstract
Objective To investigate the role of cyclophosphamide (CP) in the blood cells of Meriones unguiculatus.Methods Meriones unguiculatus were randomly divided into control group and CP group; the latter group was subdivided low-dose group and high-dose group.CP was administered intraperitoneally for 5 days.30 days after the last administration,Meriones unguiculatus blood was drawn for routine blood tests after intraperitoneal anesthesia.Results Cyclophosphamide at either dose significantly reduced the number of leukocytes (P<0.05).The percentage of lymphocytes did not differ significantly between the two CP groups and the control group (P>0.05).Low- or high-dose cyclophosphamide significantly reduced the number of erythrocytes (P<0.05 and P<0.01).However,hemoglobin concentration did not change (P>0.05); MCV,MCH,and MCHC increased,and RDW-CV had an increasing trend in the CP group,as compared with those in the control group.Cyclophosphamide induced a marked reduction in platelet level in a dose-dependent manner.Conclusions The characteristic role of cyclophosphamide in Meriones unguiculatus is as follow: it induced a marked reduction in the number of various components of leukocytes,but the effect on granulocytes may be greater than that on lymphocytes; it can significantly reduce the number of erythrocytes and induce varying degrees of anemia which may be erythrocyte proliferative anemia; it significant decreased the platelet level in dose-dependent fashion.关键词
环磷酰胺/长爪沙鼠/白细胞/血小板/红细胞Key words
Cyclophosphamide/Meriones unguiculatus/Leukocytes/Platelets/Erythrocytes引用本文复制引用
梁成结,钟欢妹,梁坤,杨僖,许楚,何秉嘉..环磷酰胺对长爪沙鼠血常规的影响[J].国际医药卫生导报,2010,16(14):1690-1692,3.
