首页|期刊导航|中华医学杂志（英文版）|Inflammatory airway features and hypothalamic-pituitary adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease
Inflammatory airway features and hypothalamic-pituitary adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease
CAI Cui CAO Yu-xue ZHANG Hong-ying LE Jing-jing DONG Jing-cheng CUI Yan XU Chang-qing LIU Bao-jun WU Jin-feng DUAN Xiao-hong
中华医学杂志（英文版）2010，Vol.123Issue(13)：1720-1726,7.
中华医学杂志（英文版）2010，Vol.123Issue(13)：1720-1726,7.DOI:10.3760/cma.j.issn.0366-6999.2010.13.020
Inflammatory airway features and hypothalamic-pituitary adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease
Inflammatory airway features and hypothalamic-pituitary adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease
摘要
Abstract
Background Bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) are both inflammatory airway diseases with different characteristics. However, there are many patients who suffer from both BA and COPD. This study was to evaluate changes of inflammatory airway features and hypothalamic-pituitary-adrenal (HPA) axis function in asthmatic rats combined with COPD.Methods Brown Norway (BN) rats were used to model the inflammatory airway diseases of BA, COPD and COPD+BA.These three models were compared and evaluated with respect to clinical symptoms, pulmonary histopathology, airway hyperresponsiveness (AHR), inflammatory cytokines and HPA axis function.Results The inflammatory airway features and HPA axis function in rats in the COPD+BA model group were greatly influenced. Rats in this model group showed features of the inflammatory diseases BA and COPD. The expression of inflammatory cytokines in this model group might be up or downregulated when both disease processes are present. The levels of corticotrophin releasing hormone mRNA and corticosterone in this model group were both significantly decreased than those in the control group (P <0.05).Conclusions BN rat can be used as an animal model of COPD+BA. By evaluating this animal model we found that the features of inflammation in rats in this model group seem to be exaggerated. The HPA axis functions in rats in this model group have been disturbed or impaired, which is prominent at the hypothalamic level.关键词
chronic obstructive pulmonary disease/bronchial asthma/inflammatory airway disease/hypothalamic-pituitary-adrenal axisKey words
chronic obstructive pulmonary disease/bronchial asthma/inflammatory airway disease/hypothalamic-pituitary-adrenal axis引用本文复制引用
CAI Cui,CAO Yu-xue,ZHANG Hong-ying,LE Jing-jing,DONG Jing-cheng,CUI Yan,XU Chang-qing,LIU Bao-jun,WU Jin-feng,DUAN Xiao-hong..Inflammatory airway features and hypothalamic-pituitary adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease[J].中华医学杂志（英文版）,2010,123(13):1720-1726,7.基金项目
This research was supported by grants from National Basic Science Program of China (No.2009CB523000) （No.2009CB523000）
Shanghai Science and Technology Committee (No.09XD1400700) and China Ministry of Education (No.200802461053). （No.09XD1400700）
