国际医药卫生导报2010，Vol.16Issue(20)：2443-2447,5.DOI:10.3760/cma.j.issn.1007-1245.2010.20.001
蛋白质质谱在肺鳞癌早期诊断中的研究
The use of plasma SELDI-TOF-MS proteomic patterns in the early detection of lung squamous cell cancers
摘要
Abstract
Objective To improve the early diagnostic rate of lung squamous cell carcinoma by using surface-enhanced desorption ionization time-of-fight mass spectrometry (SELDITOF-MS) to develop proteomic diagnosis. Methods 50 patients with lung cancer and 50 healthy individuals were detected using SELDI-TOF-MS and protein chips.The diagnostic model was established with the assistance of software and its diagnostic value was evaluated. Results There were nine peaks for the differently expressed proteins in the two groups. Three of which were highly expressed in patients with lung cancer (m/z: 9194.06, 11681.15, and 51370.19). Using tree analysis pattern, the combination of seven biomarkers (9194.06, 51370.1, 15879.1, 6624.57, 8929.80, 11681.1, and 1013.77) may identify lung cancer from normal controls with a sensitivity of 92% and a specificity of 96%.Conclusions The profiling has a high sensitivity and specificity to identify lung cancer.关键词
肺癌/鳞癌/蛋白质质谱/诊断Key words
Lung cancer/Squamous cell carcinoma/SELDI/Diagnosis引用本文复制引用
金川,张永晖,胡晓晔,周燕华,韦玉香,李惠航,李浩..蛋白质质谱在肺鳞癌早期诊断中的研究[J].国际医药卫生导报,2010,16(20):2443-2447,5.基金项目
广东省科技厅基金(2008B080703045) （2008B080703045）
