国际医药卫生导报2010，Vol.16Issue(20)：2516-2519,4.DOI:10.3760/cma.j.issn.1007-1245.2010.20.029
Rp-HPLC法测定阿莫西林、克拉维酸钾的含量
Determination of contents of amoxicillin and clavulanate potassium by Rp-HPLC
袁姗1
作者信息
- 1. 410005,长沙,湖南省人民医院药剂科
- 折叠
摘要
Abstract
Objective To establish content determination method of amoxicillin and clavulanate potassium. Methods The parameters of detection was as followed: HPLC column: Hypersil BDS C18 (4.6× 200 mum, 5μm); mobile phase: sodium dodecylsulfate solution - acetonitrile (92:8); flow: 1.0ml/min;chromatographic temperature: 25C; detection wavelength: 220 nm; injection volume: 10 μ 1. ResultsThe linear range of clavulanate potassium was good at 4.05 - 40.48 μ g ( r = 0.9999 ) and the average recovery was 99.7% (RSD = 2.1%); The linear range of amoxicillin was good at 1.15 - 11.53 μ g( r = 0.9999 )and the average recovery was 99.6% (RSD = 0.7%). Conclusions This method is accurate and easy to use, with better recovery and higher separation. It can be used for quality control of the related preparations.关键词
克拉维酸钾/阿莫西林/HPLCKey words
Clavulanate potassium/Amoxicillin/HPLC引用本文复制引用
袁姗..Rp-HPLC法测定阿莫西林、克拉维酸钾的含量[J].国际医药卫生导报,2010,16(20):2516-2519,4.
