国际医药卫生导报2010，Vol.16Issue(15)：1869-1872,4.DOI:10.3760/cma.j.issn.1007-1245.2010.15.032
尼美舒利短期治疗小儿高热的获益风险分析
The benefits and risks of short-term therapy with nimesulide for children with high fever
方爱姿 1吕胜来 2曾淑珍 1汪海洋2
作者信息
- 1. 510080,广州,广东药学院附属第一医院儿科
- 2. 527400,广东省新兴县中医院内儿科
- 折叠
摘要
Abstract
Objective To investigate the safety and efficacy of short-term therapy with nimesulide for children with high fever. Methods The efficacy of two types of antifebrile drug was assessed. 99 children with upper respiratory tract infection were randomly assigned to receive oral nimesulide (group Ⅰ), acetami-nophen (group Ⅱ), or Ibuprofen (group Ⅲ) for 3 days or shorter. The adverse reactions and the changes in body temperature after the first treatment were observed. Results The total effective rates of body temperature decrease and defervesce time in group Ⅰ were compared with those in the other two groups (P<0.01). The incidence of adverse reactions was compared between group Ⅰ and groups Ⅱ and Ⅲ(P<0.05). More children has profuse sweating in group Ⅰ than in groups Ⅱ and Ⅲ(P<O.05). Conclusions Nimesulide has a quicker onset of antifebrile, longer lasting time, less adverse reactions but causes profuse sweating more obviously. The short-term therapy with nimesulide is safe.关键词
尼美舒利/小儿/高热/非甾体类抗炎药/对乙酰氨基酚/布洛芬Key words
Nimesulide/Children/High fever/Non-steroidal anti-inflammatory drugs
Acetaminophen/lbuprofen引用本文复制引用
方爱姿,吕胜来,曾淑珍,汪海洋..尼美舒利短期治疗小儿高热的获益风险分析[J].国际医药卫生导报,2010,16(15):1869-1872,4.
