国际医药卫生导报2010，Vol.16Issue(15)：1883-1885,3.DOI:10.3760/cma.j.issn.1007-1245.2010.15.037
RP-HPLC法测定布洛芬-聚乙二醇6000固体分散体中布洛芬的含量
Use of RP-HPLC to detect the contents of ibuprofen in ibuprofen-PEG6000 solid dispersion
汤南 1徐招玉 2梁伟亮 2吴劲东2
作者信息
- 1. 523808,东莞,广东医学院药学院药分教研室
- 2. 523808,东莞,广东医学院药学院
- 折叠
摘要
Abstract
Objective To apply RP-HPLC to determine the contents of ibuprofen in ibuprofen-PEG6000 solid dispersion. Methods The separation was performed on a Shimadzu C18 column with UV detection at 264 nm, and the mobile phase consisted of 0.02 moLL-1 sodium acetate (adjusted to pH 3.0 ± 0.1 with acetic acid) -acetonitrile (40:60). The flow rate was 1.0 ml.min-1. The sample was injected at 20 μl.Results The calibration curve was linear (r = 0.999 9) within the range of 0.051 mg.ml-1 to 1.02 mg.ml-1 for ibuprofen. The average rate of retrieval was 98.40%, RSD was 0.92% (n = 9). Conclusions This method is accurate, simple, quick, and suitable for the quality control of Ibuprofen-PEG6000 solid dispersion.关键词
布洛芬/固体分散体/反相高效液相色谱法/含量测定Key words
Ibuprofen/Solid dispersion/RP-HPLC/Assay引用本文复制引用
汤南,徐招玉,梁伟亮,吴劲东..RP-HPLC法测定布洛芬-聚乙二醇6000固体分散体中布洛芬的含量[J].国际医药卫生导报,2010,16(15):1883-1885,3.
