中华医学杂志（英文版）2010，Vol.123Issue(13)：1673-1678,6.DOI:10.3760/cma.j.issn.0366-6999.2010.13.011
Ningbo thyroid dysfunction prevalence study: a cross-sectional survey in an employees-cohort
Ningbo thyroid dysfunction prevalence study: a cross-sectional survey in an employees-cohort
MAO Yu-shan 1LIU Zhi-min 2CHEN Chang-xi 1ZHU Zhong-wei 2HONG Zhong-li3
作者信息
- 1. Department of Endocrinology,Shanghai Changzheng Hospital,Second Affiliated Hospital of Second Military Medical University,Shanghai 200003,China
- 2. Department of Internal Medicine,Zhenhai Lianhua Hospital,Ningbo,Zhejiang 315207,China
- 3. Department of Cardiology,Affiliated Hospital of Ningbo University,Ningbo,Zhejiang 315003,China
- 折叠
摘要
Abstract
Background The prevalence and the spectrum of thyroid dysfunction in the mainland of China are not adequately understood. We performed a population-based study to determine the prevalence of major thyroid dysfunctions including overt and subclinical hyper- and hypothyroidism in a stable cohort.Methods All active and retired employees aged 20 years and older (11 067) of Sinopec Zhenhai Refining & Chemical Company in Ningbo participated in the cross-sectional survey with a questionnaire and blood samples. Results A total of 10 405 individuals attended for screening. Using biochemical definitions 95.5% were euthyroid. The prevalence of former diagnosed hyperthyroidism was 1.1% in females and 0.4% in males, hypothyroidism 1.7% and 0.3%, and thyroid surgery 1.2% and 0.3%, respectively. In both sex the prevalence increased with age. Twenty-four percent of individuals with thyroid surgery or medications had abnormal thyroid-stimulating hormone (TSH) levels. In individuals without a history of thyroid disease, the prevalence of pathological TSH values in females and males were TSH ≥10 mU/L 0.60% and 0.29%; TSH 4.8-9.9 mU/L 5.71 % and 2.25%; TSH <0.3 mU/L 0.87% and 0.41 %, respectively. Overt hyper- and hypothyroidism were uncommon (0.2%, 0.3%, respectively). The prevalence of subclinical hyper- and hypothyroidism was 0.4% and 3.4%, respectively. Subclinical hypothyroidism was more common in females (male 2.4% vs. female 5.8%, P<0.001) and with increasing age (P<0.001).Conclusions The prevalence of thyroid dysfunction is 4.5% in the cohort. Among individuals with thyroid medications or surgery, only 75.7% were within the normal range of TSH. These results indicate that thyroid dysfunction is common in Chinese adults.关键词
thyroid dysfunction/thyroid-stimulating hormone/epidemiologyKey words
thyroid dysfunction/thyroid-stimulating hormone/epidemiology引用本文复制引用
MAO Yu-shan,LIU Zhi-min,CHEN Chang-xi,ZHU Zhong-wei,HONG Zhong-li..Ningbo thyroid dysfunction prevalence study: a cross-sectional survey in an employees-cohort [J].中华医学杂志（英文版）,2010,123(13):1673-1678,6.
