山西医科大学学报2010，Vol.41Issue(10)：843-847,5.DOI:10.3969/J.ISSN.1007-6611.2010.10.001
脚趾截除后大鼠前扣带回锥体神经元突触传递持续性增强
Enhancement of synaptic transmission in rat anterior cingulate cortex after digit amputation
摘要
Abstract
Phantom limb pain is experienced by nearly 50%-80% of the patients following limb amputation.The anterior cingulate cortex(ACC)is a part of the limbic system that is an essential component in mediating the affective component of pain responses.To explore the role of ACC in the phantom limb pain,we recorded excitatory pestsynaptic potential(EPSP)of pyramid neurons in adult rat ACC before and after a third hind paw digit amputation using in vivo intracellular recording and staining techniques.The recorded neurons were morphologically identified as pyramidal neurons in the ACC region.The amplitude of the evoked EPSP was significantly increased 3 days after amputation and lasted for up to 7 days.The increased potentiation was associated with an increase of paired-pulse facilitation(PPF),suggesting the involvement of presynaptic component in this process.These results demonstrated that digit amputation induced a long-lasting potentiation of synaptie transmission in the pyramidal neurons of ACC in an in vivo preparation.This enhancement of synaptic transmission might contribute to the phantom limb pain.关键词
疼痛/前扣带回/兴奋性突触后电位/截肢/大鼠Key words
pain/anterior cingulate cortex/excitatory postsynaptic potential/amputation/rat分类
医药卫生引用本文复制引用
李建国,徐造诚..脚趾截除后大鼠前扣带回锥体神经元突触传递持续性增强[J].山西医科大学学报,2010,41(10):843-847,5.基金项目
美国国立卫生研究院神经病学与卒中研究所(NIH NINDS)基金资助项目(42722) （NIH NINDS）
