首页|期刊导航|中国神经再生研究（英文版）|Differential expression of 114 oxidative stressrelated genes in peripheral blood mononuclear cells of acute cerebral infarction patients A gene microarray experiment
中国神经再生研究（英文版）2010，Vol.5Issue(15)：1185-1189,5.
Differential expression of 114 oxidative stressrelated genes in peripheral blood mononuclear cells of acute cerebral infarction patients A gene microarray experiment
Differential expression of 114 oxidative stressrelated genes in peripheral blood mononuclear cells of acute cerebral infarction patients A gene microarray experiment
摘要
Abstract
Previous studies have focused on the analysis of single or several function-related genes in oxidative stress;however,little information is available regarding altered expression of oxidative stress-related genes in the process of ischemia-reperfusion injury from microarray experiments.The aim of the present study was to investigate the changes in cell oxidative stress-and toxicity-related gene expression utilizing microarray screening in patients with acute cerebral infarction during cerebral ischemia-reperfusion injury.Of the included 114 genes,expression was significantly upregulated in eight genes,including three heat shock protein-related genes,one oxidative and metabolic stress-related gene,one cell growth arrest/senescence related gene,two apoptosis signal-related genes,and one DNA damage and repair related gene.Expression was significantly downregulated in four genes,including one cell proliferation/cancer related gene,two oxidative and metabolic stress-related genes and one DNA damage and repair related gene.The results demonstrated that cerebral ischemia-reperfusion injury in patients with acute cerebral infarction was affected by many genes including oxidative stress-,heat shock-,DNA damage and repair-,and apoptosis signal-related genes.Therefore,it could be suggested that cerebral ischemia-reperfusion injury may be subjected to complex genetic regulation mechanisms.关键词
acute cerebral infarction/cerebral ischemia and reperfusion/oxidative stress/microarray/brain injury/neural regenerationKey words
acute cerebral infarction/cerebral ischemia and reperfusion/oxidative stress/microarray/brain injury/neural regeneration分类
医药卫生引用本文复制引用
Jing Yang,Fei Zhong,Mingshan Ren,Jiangming Zhao..Differential expression of 114 oxidative stressrelated genes in peripheral blood mononuclear cells of acute cerebral infarction patients A gene microarray experiment[J].中国神经再生研究（英文版）,2010,5(15):1185-1189,5.基金项目
the National Natural Science Foundation of China,No.30070829 （）
