中德临床肿瘤学杂志（英文版）2010，Vol.9Issue(10)：579-582,4.DOI:10.1007/s10330-010-0643-0
Effects of three-dimensional conformal radiotherapy on the esophageal carcinoma
Effects of three-dimensional conformal radiotherapy on the esophageal carcinoma
Hongbing Ma 1Xiaozhi Zhang 2Xijing Wang 3Meng Du 3Xinhan Zhao3
作者信息
- 1. Department of Oncology,Second Hospital,Medical College of Xi'an Jiaotong University,Xi'an 710004,China
- 2. Department of Radiation Oncology,First Hospital,Medical College of Xi'an Jiaotong University,Xi'an 710061,China
- 折叠
摘要
Abstract
Objective:Radiation therapy is an important component of the multidisciplinary management of esophageal carcinoma.Three-dimensional conformal radiation therapy requires the precise definition of the target volume.We aimed to compare the treatment results and radiation toxicities between three-dimensional conformal radiotherapy (3D-CRT) and conventional radiotherapy (CR) for patients with cervical and thoracic esophageal carcinoma.Methods:From June 2004 to December 2006,a random study was performed on 106 patients treated with 3D-CRT or CR,53 patients in each group.The patients in CR group received conventional radiotherapy in 2.0 Gy/f,5 f/week and total dose was 66-70 Gy in 6.5 or 7 weeks.The patients in 3D-CRT group were treated by 3D-CRT in 2.0 Gy/f,5 f/week and total dose was 64-70 Gy in 6 weeks.The local control rates,survival rates and radiation toxicities for the two groups were investigated.Results:The 1-year and 3-year local control rates were 83.0% and 60.4% in 3D-CRT group and 64.2% (X2=4.853,P=0.028) and 32.1% (X2=9.812,P=0.002) in CR group.The 1-year and 3-year survival rates were 73.6% and 50.9% in 3D-CRT group and 54.7% (X2=4.102,P=0.043) and 32.1% (X2=3.886,P=0.049) in CR group.Between the two groups,there was no significant difference in radiation toxicities.Conclusion:The 1-year and 3-year local control rates and survival rates of patients with esophageal carcinoma treated by 3D-CRT is supedor to CR.However,longer-term results and radiation toxicity need further study which involves more patients and prolonged follow-up.关键词
esophageal carcinoma/three-dimensional conformal radiotherapy/conventional radiotherapyKey words
esophageal carcinoma/three-dimensional conformal radiotherapy/conventional radiotherapy分类
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Hongbing Ma,Xiaozhi Zhang,Xijing Wang,Meng Du,Xinhan Zhao..Effects of three-dimensional conformal radiotherapy on the esophageal carcinoma[J].中德临床肿瘤学杂志（英文版）,2010,9(10):579-582,4.
