中国神经再生研究（英文版）2010，Vol.5Issue(17)：1324-1329,6.DOI:10.3969/j.issn.1673-5374.2010.17.008
Role of Dicer on tumorigenesis in glioma cells
Role of Dicer on tumorigenesis in glioma cells
摘要
Abstract
Micro RNAs(miRNAs)are non-coding,single-stranded RNAs that regulate target gene expression by repressing translation or promoting RNA cleavage.Recent studies show that miRNA expression is globally decreased in some human tumors.Dicer is an essential component of the miRNA processing machinery.To determine whether global reduction of miRNA effects tumorigenesis,small interfering RNA were designed to target Dicer to restrain whole miRNA expression in the glioblastoma cell line-TJ905.With effective knock-down of Dicer,tumor cells were invasive and proliferative,and globally impaired miRNA processing enhanced proliferation and invasiveness of glioma cells in vitro.Suppression of Dicer expression resulted in a more aggressive glioma phenotype,which suggests that global reduction of miRNA expression could have an oncogenic role in glioblastoma cells.关键词
Dicer/glioma/tumorigenesis/small interfering RNA/micro RNAsKey words
Dicer/glioma/tumorigenesis/small interfering RNA/micro RNAs分类
医药卫生引用本文复制引用
Anling Zhang,Lei Han,Guangxiu Wang,Zhifan Jia,Peiyu Pu,Chunsheng Kang..Role of Dicer on tumorigenesis in glioma cells[J].中国神经再生研究（英文版）,2010,5(17):1324-1329,6.基金项目
Supported by:New Century Excellent Talents in University,Ministry of Education,No.NCET-07-0615 （）
the National Natural Science Foundation of China,No.30971136 （）
Tianjin Research Program of Application Foundation and Advanced Technology,No.09JCZDJC17600 （）
