中国神经再生研究（英文版）2010，Vol.5Issue(17)：1308-1312,5.DOI:10.3969/j.issn.1673-5374.2010.17.005
Changes in blood-brain barrier permeability and expression of related factors in a rat model of intracerebral hemorrhage following minocycline treatment
Changes in blood-brain barrier permeability and expression of related factors in a rat model of intracerebral hemorrhage following minocycline treatment
Wei Shi 1Zizhang Wang 1Jingnan Pu 1Ruizhi Wang 1Zhenyu Guo 1Chongxiao Liu 1Jianjun Sun 1Ligui Gao 1Ren Zhou1
作者信息
摘要
Abstract
Inflammatory factor aggregation and blood-brain barrier(BBB)damage occur around hematoma foci following intracerebral hemorrhage.Minocycline is lipophilic,can pass through the BBB,and shows anti-inflammatory effects in models of central nervous system disease.We found that minocycline application at 6 hours after intracerebral hemorrhage reduced BBB permeability,decreased vascular endothelial growth factor expression,and increased nerve growth factor and heat shock protein 70 expression,primarily in neurons and microglia.Early intraperitoneal injection of minocycline attenuated BBB damage possibly by reducing vascular endothelial growth factor expression and enhancing nerve growth factor and heat shock protein 70 expression.关键词
blood-brain barrier/intracerebral hemorrhage/vascular endothelial growth factor/nerve growth factor/heat shock protein 70/therapyKey words
blood-brain barrier/intracerebral hemorrhage/vascular endothelial growth factor/nerve growth factor/heat shock protein 70/therapy分类
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Wei Shi,Zizhang Wang,Jingnan Pu,Ruizhi Wang,Zhenyu Guo,Chongxiao Liu,Jianjun Sun,Ligui Gao,Ren Zhou..Changes in blood-brain barrier permeability and expression of related factors in a rat model of intracerebral hemorrhage following minocycline treatment[J].中国神经再生研究（英文版）,2010,5(17):1308-1312,5.
