首页|期刊导航|中国神经再生研究（英文版）|Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury

Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury

Dawei Sun Huamin Liu Fugao Zhu Yanqing Wang Junfeng Wen Rui Zhou Yanjun Wang Banghua Liu

中国神经再生研究（英文版）2010，Vol.5Issue(18)：1418-1422,5.

中国神经再生研究（英文版）2010，Vol.5Issue(18)：1418-1422,5.DOI:10.3969/j.issn.1673-5374.2010.18.010

Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury

Dawei Sun ¹Huamin Liu ²Fugao Zhu ³Yanqing Wang ⁴Junfeng Wen ⁵Rui Zhou ⁶Yanjun Wang ⁶Banghua Liu⁶

作者信息

1. Department of Otolaryngology-Head and Neck Surgery,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China
2. Department of Oncology,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China
3. Department of Science and Education,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China
4. School of Public Health,Shandong University,Jinan 250012,Shandong Province,China
5. Department of Otolaryngology-Head and Neck Surgery,Union Hospital of Huazhong University of Science and Technology,Wuhan430022,Hubei Province,China
折叠

摘要

Abstract

The muscarinic receptor modulates intracellular free calcium ion levels in the facial nerve nucleus via different channels.In the present study,muscarinic receptor-mediated free calcium ions levels were detected by confocal laser microscopy in the facial nerve nucleus following facial nerve injury in rats.There was no significant difference in muscarinic receptor expression at the affected facial nerve nucleus compared with expression prior to injury,but muscarinic receptor-mediated free calcium ion levels increased in the affected side following facial nerve injury(P < 0.01).At day 30after facial nerve injury,50 μmol/L muscarinic-mediated free calcium ion levels were significantly inhibited at the affected facial nerve nucleus in calcium-free artificial cerebrospinal fluid,and the change range was 82% of artificial cerebrospinal fluid(P < 0.05).These results suggest that increased free calcium ion concentrations are achieved by intracellular calcium ion release,and that the transmembrane flow of calcium ions is also involved in this process.

关键词

facial nerve injury/muscarinic receptor/facial nerve nucleus/calcium ion/thapsigargin

Key words

facial nerve injury/muscarinic receptor/facial nerve nucleus/calcium ion/thapsigargin

分类

医药卫生

引用本文复制引用

Dawei Sun,Huamin Liu,Fugao Zhu,Yanqing Wang,Junfeng Wen,Rui Zhou,Yanjun Wang,Banghua Liu..Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury[J].中国神经再生研究（英文版）,2010,5(18):1418-1422,5.

基金项目

The study was sponsored by the Youth Research Foundation of Qingdao University (2007). （2007）

中国神经再生研究（英文版）

OACSCDSCI

ISSN：1673-5374

访问量0

下载量0

段落导航