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Picroside Ⅱ down-regulates matrix metalloproteinase-9 expression following cerebral ischemia/reperfusion injury in rats

Xiang Li Xinying Xu Zhen Li Yunliang Guo Qin Li Xiaodan Li Zhen Zhou

中国神经再生研究（英文版）2010，Vol.5Issue(18)：1403-1407,5.

中国神经再生研究（英文版）2010，Vol.5Issue(18)：1403-1407,5.DOI:10.3969/j.issn.1673-5374.2010.18.007

Picroside Ⅱ down-regulates matrix metalloproteinase-9 expression following cerebral ischemia/reperfusion injury in rats

Xiang Li ¹Xinying Xu ²Zhen Li ³Yunliang Guo ⁴Qin Li ⁵Xiaodan Li ⁵Zhen Zhou⁵

作者信息

1. Department of Ultrasound,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China
2. Institute of Cerebrovascular Disease,Qingdao University Medical College,Qingdao 266003,Shandong Province,China
3. Yuhuangding Hospital,Qingdao University Medical College,Qingdao 266003,Shandong Province,China
4. Experimental Center of Surgery,Qingdao University Medical College,Qingdao 266003,Shandong Province,China
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摘要

Abstract

Studies have shown that Picroside Ⅱ attenuates inflammatory reactions following brain ischemia through the inhibition of the TLR-4-NF-κB signal transduction pathway,and ameliorates cerebral edema through the reduction of aquaporin-4 expression.Matrix metalloproteinase-9(MMP-9),located downstream of the TLR-4-NF-κB signal transduction pathway,can degrade the neurovascular matrix,damage the blood-brain barrier to induce cerebral edema,and directly result in neuronal apoptosis and brain injury.Therefore,the present study further observed MMP-9expression in the brain tissues of rats with cerebral ischemia/reperfusion injury following Picroside Ⅱtreatment.Results demonstrated that Picroside Ⅱ significantly reduced MMP-9 expression in ischemic brain tissues,as well as neuronal apoptosis and brain infarct volume,suggesting PicrosideⅡ exhibits neuroprotection by down-regulating MMP-9 expression and inhibiting cell apoptosis.

关键词

Picroside Ⅱ/cerebral ischemia/reperfusion injury/apoptosis/matrix metalloproteinase-9/rats/neural regeneration

Key words

Picroside Ⅱ/cerebral ischemia/reperfusion injury/apoptosis/matrix metalloproteinase-9/rats/neural regeneration

分类

医药卫生

引用本文复制引用

Xiang Li,Xinying Xu,Zhen Li,Yunliang Guo,Qin Li,Xiaodan Li,Zhen Zhou..Picroside Ⅱ down-regulates matrix metalloproteinase-9 expression following cerebral ischemia/reperfusion injury in rats[J].中国神经再生研究（英文版）,2010,5(18):1403-1407,5.

基金项目

The project was financially supported by the National Natural Science Foundation of China (Treatment effect of Picroside Ⅱ on ischemic stroke), No. 30873391. （Treatment effect of Picroside Ⅱ on ischemic stroke）

中国神经再生研究（英文版）

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ISSN：1673-5374

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