首页|期刊导航|中华医学杂志（英文版）|Clinical and prognostic characteristics of 573 cases of primary Sj(o)gren's syndrome
中华医学杂志（英文版）2010，Vol.123Issue(22)：3252-3257,6.DOI:10.3760/cma.j.issn.0366-6999.2010.22.015
Clinical and prognostic characteristics of 573 cases of primary Sj(o)gren's syndrome
Clinical and prognostic characteristics of 573 cases of primary Sj(o)gren's syndrome
摘要
Abstract
Background Primary Sj(o)gren's syndrome (pSS) is one of the autoimmune diseases with high incidence. There were several clinical investigations in Caucasian but seldom in Chinese. The aim of this study was to compare the difference of clinical manifestations, immunological features and prognosis of pSS between Caucasian and Chinese pSS patients.Methods Five hundred and seventy-three patients who fulfilled the 2002 international classification (criteria) for pSS from Peking Union Medical College Hospital between 1985 and 2006 were screened retrospectively and compared with other populations.the onset of the disease was (39.0±13.7) years and in 169 (29.5%) patients the disease onset occurred before the age of 30 years. The average duration from disease onset to pSS diagnosis was 48 months (range, 1-552 months). It had been shortened during the recent five years. (2) Dry mouth (84.5%) and dry eyes (70.0%) were the most common symptoms,significantly lower than foreign patients (P=0.000). Two hundred and seventy-two (47.5%) patients presented with rampant caries, 160 (27.9%) with parotidomegaly. The positivity of xerostomia, xerophthalmia and salivary gland biopsy were 91.9%, 94.8% and 90.7%, respectively. (3) Systemic involvement occurred in 91.4% patients. Compared with studies done outside China, higher prevalence of fever 41.0%, myositis 4.9%, pericardial effusion 14.8%, pulmonary involvement 42.3%, renal involvement 33.5%, thyroid involvement 32.7%, pancrease involvement 5.6% (P ＜0.01) and lower prevalence of fatigue, lymphadenectasis and Raynaud's phenomenon (P ＜0.01) were seen. (4) Risk factors of death include pulmonary artery hypertension, liver damage and interstitial lung disease.Conclusions Chinese pSS differs significantly from the non-Chinese cases in terms of the age of onset, systemic involvement, autoantibodies and proportional mortality rate. Lung and liver damage were found to be the highest risk factors of the disease prognosis.关键词
Sj(o)gren's syndrome/prevalence/prognosisKey words
Sj(o)gren's syndrome/prevalence/prognosis分类
医药卫生引用本文复制引用
LIN Dong-fang,YAN Shu-min,ZHAO Yan,ZHANG Wen,LI Meng-tao,ZENG Xiao-feng,ZHANG Feng-chun,DONG Yi..Clinical and prognostic characteristics of 573 cases of primary Sj(o)gren's syndrome[J].中华医学杂志（英文版）,2010,123(22):3252-3257,6.基金项目
This study was supported by grants from Key Projects in the National Science and Technology Pillar Program in the Eleventh Five-Year Plan (No. 2008BAI59B02 and 2008BAI59B03). （No. 2008BAI59B02 and 2008BAI59B03）
