中华医学杂志（英文版）2010，Vol.123Issue(22)：3238-3242,5.DOI:10.3760/cma.j.issn.0366-6999.2010.22.012
Genetic polymorphisms of the renin-angiotensin-aldosterone system in Chinese patients with end-stage renal disease secondary to IgA nephropathy
Genetic polymorphisms of the renin-angiotensin-aldosterone system in Chinese patients with end-stage renal disease secondary to IgA nephropathy
HUANG Hai-dong 1LIN Fu-jun 1LI Xin-juan 1WANG Li-rui 1JIANG Geng-ru1
作者信息
摘要
Abstract
Background Genetic variability in the renin-angiotensin-aldosterone system may modify renal responses to injury and disease progression. The angiotensin l-converting enzyme (ACE) gene insertion/deletion (l/D), the angiotensinogen (AGT) gene, M235T, the aldosterone synthase (CYP11B2) gene, C-344T, and the angiotensin Ⅱ type 1 receptor (AT1 R)gene, A1166C, have been shown to be associated with IgA nephropathy (IgAN) and its progression. We determined the presence of these polymorphisms in 130 Chinese patients with IgAN, including 47 patients with end-stage renal disease (ESRD) and 120 healthy Chinese subjects, to assess their impact on the susceptibility to disease and the liability of progression to ESRD.Methods Genotyping was performed with DNA isolated from peripheral leucocytes using polymerase chain reaction amplification of the polymorphic sequence, restriction enzyme digestion, and separation and identification of DNA fragments. Clinical data from renal biopsies were collected.Results ACE, AGT, CYP and AT1R genotype distributions were similar in patients with lgAN and in controls. Comparing patients with ESRD (IgAN-ESRD) and those without ESRD (IgAN-non ESRD), there was a significant increase only in the ACE DD genotype (P ＜0.05) among the four gene polymorphisms. There was significant dominance of the male (P ＜0.05), more marked hypertension (P ＜0.01), proteinuria (P ＜0.01) and increased serum creatinine during renal biopsy (P ＜0.01) in the IgAN-ESRD group.Conclusion Among the ACE, AGT, AT1R and CYP gene polymorphisms, only the DD genotype may predispose the individual to increased risk of progression to ESRD in the Chinese population.关键词
IgA nephropathy/end-stage renal disease/genetic polymorphism/renin-angiotensin-aldosterone systemKey words
IgA nephropathy/end-stage renal disease/genetic polymorphism/renin-angiotensin-aldosterone system分类
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HUANG Hai-dong,LIN Fu-jun,LI Xin-juan,WANG Li-rui,JIANG Geng-ru..Genetic polymorphisms of the renin-angiotensin-aldosterone system in Chinese patients with end-stage renal disease secondary to IgA nephropathy[J].中华医学杂志（英文版）,2010,123(22):3238-3242,5.
