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Remodeling of skin nerve fibers during burn wound healing

Yongqiang Feng Xia Li Rui Zhang Yu Liu Tingting Leng Yibing Wang

中国神经再生研究（英文版）2010，Vol.5Issue(19)：1515-1520,6.

中国神经再生研究（英文版）2010，Vol.5Issue(19)：1515-1520,6.DOI:10.3969/j.issn.1673-5374.2010.19.014

Remodeling of skin nerve fibers during burn wound healing

Yongqiang Feng ¹Xia Li ²Rui Zhang ³Yu Liu ⁴Tingting Leng ⁵Yibing Wang⁵

作者信息

1. Department of Burn and Plastic Surgery,Provincial Hospital Affiliated to Shandong University,Jinan 250021,Shandong Province,China
2. Department of Burn,Weihai Municipal Hospital,Weihai 264200,Shandong Province,China
3. Department of Pathology,Shandong Medical College,Jinan 250002,Shandong Province,China
4. Department of Pathology,Provincial Hospital Affiliated to Shandong University,Jinan 250021,Shandong Province,China
折叠

摘要

Abstract

Burn wound healing involves a complex sequence of processes.Recent studies have revealed that skin reinnervation may have an impact on physiological wound repair.Few studies have addressed the process of reinnervation and morphological changes in regenerated nerve fibers.The regeneration of neurites during full-thickness burn wound healing was determined by immunofluorescent staining using an anti-neurofilament protein monoclonal antibody,and three-dimensional morphology was observed under a laser scanning confocal microscope.Morphology and the volume fraction of collagen and nerve fibers were measured.Skin reinnervation increased during wound healing,peaked during the proliferative scar stage,and then decreased to lower levels during the maturation period.The results from the skin nerve fibers correlated with those from collagen using semi-quantitative analysis.Disintegration and fragmentation were observed frequently in samples from the proliferative stage,and seldom occurred during the maturation stage.There was a remodeling process of regenerated nerve fibers during wound healing,which comprised changed innervation density and topical morphology.The mechanism of remodeling for nerve fibers requires further investigation.

关键词

burns/scar/wound healing/collagen/nerve fibers/reinnervation/tissue remodeling/neural regeneration

Key words

burns/scar/wound healing/collagen/nerve fibers/reinnervation/tissue remodeling/neural regeneration

分类

医药卫生

引用本文复制引用

Yongqiang Feng,Xia Li,Rui Zhang,Yu Liu,Tingting Leng,Yibing Wang..Remodeling of skin nerve fibers during burn wound healing[J].中国神经再生研究（英文版）,2010,5(19):1515-1520,6.

基金项目

This study was supposed by the Natural Science Foundation of Shandong Province (Study of neuronal architectonics in human normal skin and scar tissue),No.Y2002C29. （Study of neuronal architectonics in human normal skin and scar tissue）

中国神经再生研究（英文版）

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ISSN：1673-5374

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