中国神经再生研究（英文版）2010，Vol.5Issue(19)：1505-1509,5.DOI:10.3969/j.issn.1673-5374.2010.19.012
Sevoflurane and nitric oxide synthase expression in rat cochlea
Sevoflurane and nitric oxide synthase expression in rat cochlea
摘要
Abstract
Sevoflurane exhibits anesthetic action by inhibiting the auditory cortex,brain stem nitric oxide synthase activity,and reducing nitric oxide(NO),thereby interfering with the hearing process.However,the influence of sevoflurane on peripheric receptor(cochlea)NO remains poorly understood.Results from the present study showed that sevoflurane downregulated cochlear inducible NO synthase,endothelial NO synthase and neuronal NO synthase expression in a dose dependent manner.This suggests that sevoflurane can decrease cochlear NO synthase expression in a dose dependent manner.关键词
sevoflurane/cochlea/nitric oxide synthase/nitric oxide/ratsKey words
sevoflurane/cochlea/nitric oxide synthase/nitric oxide/rats分类
医药卫生引用本文复制引用
Yuantao Li,Qingzhong Hou,Mingguang Wu,Xiaolei Huang,Jun Cao,Yin Gu,Xiaofei Qi,Yawen Li..Sevoflurane and nitric oxide synthase expression in rat cochlea[J].中国神经再生研究（英文版）,2010,5(19):1505-1509,5.基金项目
This project was financially supported by the Key Program of the Hubei Provincial Education Department (Effect of propofol on rat auditory brainstem nucleus),No.D200524008 （Effect of propofol on rat auditory brainstem nucleus）
the Scientific Research Foundation Program of Hubei Provincial Health Department (Inhalation anesthetics on headng damage),No.JX2C32. （Inhalation anesthetics on headng damage）
