中国组织工程研究与临床康复2010，Vol.14Issue(42)：7966-7970,5.DOI:10.3969/j.issn.1673-8225.2010.42.043
镁锌合金与大鼠肠道的生物相容性
Biocompatibility of a magnesium-zinc alloy implanted in rat cecum
摘要
Abstract
BACKGROUND: Magnesium alloy studies in orthopedic field have been carried out,and good biocompatibility has been reported.However magnesium alloys have not yet been researched in the intestine.OBJECTIVE: The biodegradable magnesium-zinc alloy samples are implanted around the rat cecum to investigate the biocompatibility in rat.METHODS: Sprague Dawley rats were randomly divided into magnesium alloy group,medical titanium group and the sham-operated group.Then magnesium-zinc alloy samples with the dimension of 5 mm × 1 mm× 1 mm were embedded in the cecum incision in the magnesium alloy group.The medical titanium was embedded in the medical titanium group,and just suture in the sham-operated group.Prior to surgery and at 7,14,21 and 28 days after operation,the serum glutamic-oxaloacetic transaminase,creatinine and magnesium ion concentration were examined in each group.X-ray film on implanted region.The pathological changes in liver,kidney and cecum were examined.RESULTS AND CONCLUSION: There were no significant differences in serum glutamic-oxaloacetic transaminase,creatinine and magnesium ion concentrations among each group(P > 0.05).Magnesium-zinc alloy degraded gradually during 28 days.The pathology of liver,kidney and cecum was normal.Results suggested that magnesium-zinc alloy had no obvious effect on the cecum.The degradation time to play a fixed function of time was longer than the intestinal healing time,with good biocompatibility.Magnesium-zinc alloy can be used as anastomotic nail for stomach intestine anastomat.关键词
可降解/镁合金/大鼠盲肠/肝肾功能/生物相容性分类
医药卫生引用本文复制引用
袁青领,阎钧,郑起,张绍翔,张小农..镁锌合金与大鼠肠道的生物相容性[J].中国组织工程研究与临床康复,2010,14(42):7966-7970,5.基金项目
国家自然科学基金资助(30901422).课题名称:可降解金属镁合金与肠上皮细胞的分子生物相容性研究. Supported by:the National Natural Science Foundation of China,No.30901422 （30901422）
