中华医学杂志（英文版）2010，Vol.123Issue(21)：3110-3117,8.DOI:10.3760/cma.j.issn.0366-6999.2010.21.029
Role of interventional endovascular therapy for delayed hemorrhage after pancreaticoduodenectomy
Role of interventional endovascular therapy for delayed hemorrhage after pancreaticoduodenectomy
WANG Zhi-jun 1WANG Mao-qiang 1LIU Feng-yong 1DUAN Feng 1SONG Peng 1FAN Qing-sheng1
作者信息
摘要
Abstract
Background Delayed massive hemorrhage (DMH) after pancreaticoduodenectomy (PD) is a sedous complication and one of the most common causes of mortality after PD. Its ideal management remains unclear. This paper is to present our experience in the endovascular treatment of patients with DMH after PD using different techniques and materials.Methods During a seven years period, 19 patients (fifteen men, four women) with DMH arter PD were treated with endovascular procedures, including transcatheter arterial embolization (TAE) with coils embolization in eight cases, with coils plus N-butyl-2-cyanoacrylate (NBCA)-Lipiodol mixture in six cases, and stent-graft placement in five cases. The mean age of the patients was 58.2 years. Follow-up, including clinical condition, liver function tests, and Doppler ultrasound examinations, was documented.Results The immediate technical success rate was 84.2% (16/19). There were no significant procedure-related complications. Hemostasis was not achieved with interventional procedures in three patients: one died of uncontrolled bleeding four days after the second TAE, and two patients required emergency laparotomy without re-angiography because of worsening clinical status. Among the 16 patients with successfully stopped bleeding who became hemodynamically stable after the procedure without evidence of further bleeding, two patients died during the peri-interventional procedure period because of multiple organ failure, and fourteen patients survived to hospital discharge. The mean length of follow-up was 14.6 months. Recurrent bleeding after discharge did not occur in any of these cases. Clinical and laboratory follow-up findings were unremarkable. Doppler ultrasound examinatation verified patency of the hepatic artery in the four patients with stent-graft placement during the follow-up period (5 months-29 months; mean, 15.3 months).Conclusions Interventional endovascular procedure is a safe and technically feasible solution to control DMH. The first-line treatment for the bleeding is TAE. Stent-graft placement with preservation of the organ arterial flow, if technicallypossible, is a valuable alternative to TAE and surgical intervention for management of DMH.关键词
pancreaticoduodenectomy/delayed massive hemorrhage/hepatic artery/pseudoaneurysm/interventional radiologyKey words
pancreaticoduodenectomy/delayed massive hemorrhage/hepatic artery/pseudoaneurysm/interventional radiology分类
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WANG Zhi-jun,WANG Mao-qiang,LIU Feng-yong,DUAN Feng,SONG Peng,FAN Qing-sheng..Role of interventional endovascular therapy for delayed hemorrhage after pancreaticoduodenectomy[J].中华医学杂志（英文版）,2010,123(21):3110-3117,8.
