国际医药卫生导报2010，Vol.16Issue(21)：2584-2589,6.DOI:10.3760/cma.j.issn.1007-1245.2010.21.005
Gd-DTPA对胶质瘤磁共振波谱分析的影响研究
Impact of Gd-DTPA on magnetic resonance spectroscopy analysis of glioma
摘要
Abstract
Objective To explore the impact of Gd-DTPA, a contrast agent, on proton magnetic resonance spectroscopy analysis of glioma. Methods MRI scans were performed in 28 patients with glioma ( 13 Ⅲ grade anaplastic astrocytoma and15 Ⅳ grade glioblastoma), includingT1WI axial and sagittal scans,T2WI axial, T2WI axial FLAIR scans. The maximum levels of tumors in the FLAIR sequence were selected as views of interest for three dimension multi-or single-voxel proton spectroscopy scanning. After injection of 15ml of Gd-DTPA, enhanced MRI scans were performed and the level of marked enhancement in tumors were selected. 1H-MRS were performed again, consistent with the plain MRS scans in location and scanning parameters. Philips spectral analysis software was used to compare the values of NAA, Cr, Cho, NAA/Cr,Cho/Cr, and NAA/Cho before and after injertion of contrast agent in enhancement area glioma. Results The values of NAA, Cr, Cho, NAA/Cr, Cho/Cr, and NAA/Cho in plain and enhanced glioma MRS in the lesion enhancement area were ( 0.20 ± 0.08, 0.19 ± 0.09 ), ( 0.24 ± 015, 0.23 ± 0.15 ), ( 0.51 ±0.16, 0.53 ± 0.17 ), ( 1.02 ± 0.69, 0.99 ± 0.63 ), ( 2.76 ± 1.46, 2.79 ± 1.51 ), and ( 0.41 ± 0.20,0.38 ± 0.17 ); with no significant differences ( P> 0.05 ). Conclusion Gd-DTPA has no effect on the quality of spectral images. 1H-MRS should be performed after enhanced scans, which can more accurately reflect the metabolic activity of the lesions.关键词
磁共振波谱分析/增强扫描/对比剂/胶质瘤Key words
Magnetic resonance spectroscopy/Enhanced scan/Contrast agent/Glioma分类
医药卫生引用本文复制引用
李伟,龙晚生,罗学毛,蔡小琴,兰勇,何义改..Gd-DTPA对胶质瘤磁共振波谱分析的影响研究[J].国际医药卫生导报,2010,16(21):2584-2589,6.基金项目
江门市科技攻关项目(江科2010[73]-1) （江科2010[73]-1）
