首页|期刊导航|中华医学杂志（英文版）|Reconstruction of orbital defect in rabbits with composite of calcium phosphate cement and recombinant human bone morphogenetic protein-2
中华医学杂志（英文版）2010，Vol.123Issue(24)：3658-3662,5.DOI:10.3760/cma.j.issn.0366-6999.2010.24.027
Reconstruction of orbital defect in rabbits with composite of calcium phosphate cement and recombinant human bone morphogenetic protein-2
Reconstruction of orbital defect in rabbits with composite of calcium phosphate cement and recombinant human bone morphogenetic protein-2
摘要
Abstract
Background Calcium phosphate cement (CPC) is a biocompatible and osteoconductive bone substitute, and recombinant human bone morphogenetic protein-2 (rhBMP-2) has strong osteoinductibility, therefore we developed a composite bone substitute with CPC and rhBMP-2 and evaluate its reconstruction effect in rabbit orbital defect.Methods Thirty-six rabbits were randomly divided into two groups and a 5 mmx5 mmx2 mm bone defect in the infraorbital rim was induced by surgery in each orbit (72 orbits in all). The orbital defects were treated with pure CPC or composite of CPC and rhBMP-2. The osteogenesis ability of different bone substitute was evaluated by gross observation, histological examination, histomorphometrical evaluation, compressive load-to-failure testing, and scanning electron microscope (SEM).Results Gross observation showed that both bone substitutes were safe and effective for reconstruction of orbital defect. However, histological examination, histomorphometrical evaluation and SEM showed that CPC/rhBMP-2 group had faster speed in new bone formation and degradation of substitute material than CPC group. Compressive load-to-failure testing showed that CPC/rhBMP-2 group had stronger compressive strength than CPC group at every stage with significant difference (P ＜0.05).Conclusion Composite of CPC/rhBMP-2 is an ideal bioactive material for repairing orbital defect, with good osteoconductibility and osteoinductibility.关键词
orbital defect/calcium phosphate cement/recombinant human bone morphogenetic protein-2Key words
orbital defect/calcium phosphate cement/recombinant human bone morphogenetic protein-2分类
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ZHENG Yong-xin,WANG Jing,LIN Hao-tian,LI Ling..Reconstruction of orbital defect in rabbits with composite of calcium phosphate cement and recombinant human bone morphogenetic protein-2[J].中华医学杂志（英文版）,2010,123(24):3658-3662,5.基金项目
This study was supported by grants from Guangdong Natural Science Foundation (No. 3030902105013), Guangdong Provincial Science and Technology program ( No. 2008B030301067). （No. 3030902105013）
