Transforming growth factor-β1 involved in urotensin Ⅱ-induced phenotypic differentiation of adventitial fibroblasts from rat aortaOACSCDCSTPCD
Transforming growth factor-β1 involved in urotensin Ⅱ-induced phenotypic differentiation of adventitial fibroblasts from rat aorta
Background Urotensin Ⅱ (UⅡ) is a new vasoconstrictive peptide that may activate the adventitial fibroblasts.Transforming growth factor-β1 (TGF-β1) is an important factor that could induce the phenotypical transdifferentiation of adventitial fibroblasts. This study aimed to explore whether TGF-β1 is involved in UⅡ-induced phenotypic differentiation of adventitial fibroblasts from rat aorta.Methods Adventitial fibroblasts were prepared by the explant culture m…查看全部>>
ZHANG Yong-gang;HU Yan-chao;MAO Yan-yan;WEI Rui-hong;BAO Shi-lin;WU Li-biao;KUANG Ze-jian
Department of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China Laboratory of Molecular Biology and Cardiology, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, ChinaDepartment of Cardiovascular Diseases, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, ChinaDepartment of Internal Medicine, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, ChinaLaboratory of Molecular Biology and Cardiology, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China
临床医学
urotensin Ⅱtransforming growth factor-β1adventitial fibroblastsphenotypic differentiationvascular fibrosis
urotensin Ⅱtransforming growth factor-β1adventitial fibroblastsphenotypic differentiationvascular fibrosis
《中华医学杂志（英文版）》 2010 (24)
尾加压素II促进血管外膜成纤维细胞表型转变的机制研究
3634-3639,6
This project was supported by grants from the National Natural Science Foundation of China (No. 30470730, No. 30971273), the Natural Science Foundation of Guangdong Province (No.9151051501000016), and the Medical Scientific Research Foundation of Guangdong Province, China(No.A2007425).
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