中华医学杂志（英文版）2010，Vol.123Issue(24)：3554-3558,5.DOI:10.3760/cma.j.issn.0366-6999.2010.24.010
IMP3 is a novel biomarker to predict metastasis and prognosis of gastric adenocarcinoma: a retrospective study
IMP3 is a novel biomarker to predict metastasis and prognosis of gastric adenocarcinoma: a retrospective study
WANG Lin 1LI Hai-gang 2XIA Zhong-sheng 3L(U) Jun 4PENG Ting-sheng5
作者信息
- 1. Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China
- 2. Department of Gastroenterology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China
- 3. Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China
- 4. Department of Pathology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China
- 折叠
摘要
Abstract
Background Insulin-like growth factor-Ⅱ mRNA-binding protein 3 (IMP3) is a newly identified mRNA-binding protein that is involved in embryogenesis and carcinogenesis of some malignant tumors. The aim of this study was to detect the expression of IMP3 protein in gastric adenocarcinoma (GAC) and the correlation with clinicopathological features.Methods IMP3 protein in 92 samples of GAC was evaluated by immunohistochemical method. The Mann-Whitney U test and Kruskal-Wallis H test were used to compare IMP3 expression and clinicopathological parameters. Kaplan-Meier survival curve, log-rank test and Cox-regression model were used to evaluate the correlation of IMP3 protein expression to the prognosis of patients.Results Out of 92 cases of adjacent normal mucosa (ANM), 10 with dysplasia demonstrated weak expression of IMP3 and 82 without dysplasia showed negative expression. Out of 92 cases of GAC, positive immunohistochemical stain for IMP3 was identified in 75 (82%) cases. A comparison of IMP3 expression in GAC and ANM showed stronger immunohistochemical reactivity in GAC (P ＜0.05). High expression of IMP3 was found to be associated with lymphoid metastasis, high Ki-67 labelling index, and patient poor outcome (P ＜0.05). There was a significant TNM stage difference between GAC with and without IMP3 expression (P＜0.05). Tumors with higher stage showed higher level of IMP3 expression, In multivariate analysis, IMP3 emerged as an independent predictor of survival.Conclusions Increase of IMP3 expression suggests that IMP3 may play an importent role in the carcinogenesis and tumor metastasis in GAC. It could be regarded as a novel proliferation and prognostic indicator for patients with GAC.关键词
stomach neoplasms/IMP3 protein,human/immunohistochemistry/prognosisKey words
stomach neoplasms/IMP3 protein,human/immunohistochemistry/prognosis分类
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WANG Lin,LI Hai-gang,XIA Zhong-sheng,L(U) Jun,PENG Ting-sheng..IMP3 is a novel biomarker to predict metastasis and prognosis of gastric adenocarcinoma: a retrospective study[J].中华医学杂志（英文版）,2010,123(24):3554-3558,5.
