首页|期刊导航|中国神经再生研究（英文版）|Sodium glutamate and gamma-aminobutyric acid affect iron metabolism in the rat caudate putamen
中国神经再生研究（英文版）2010，Vol.5Issue(21)：1644-1649,6.DOI:10.3969/j.issn.1673-5374.2010.21.008
Sodium glutamate and gamma-aminobutyric acid affect iron metabolism in the rat caudate putamen
Sodium glutamate and gamma-aminobutyric acid affect iron metabolism in the rat caudate putamen
摘要
Abstract
Glutamic acid and gamma-aminobutyric acid (GABA) influence iron content in the substantia nigra and globus pallidus, although the mechanisms of action remain unclear. The present study measured iron content and changes in divalent metal transporter 1 (DMT1) and hephaestin expression in the substantia nigra and caudate putamen, and explored the effects of GABA and glutamic acid on iron metabolism, Results demonstrated that iron content and DMT1 non iron response element [DMT1 (-IRE)] expression were significantly greater but hephaestin expression was significantly lower in the caudate putamen of the monosodium glutamate group compared with the control group. No significant difference in iron content was detected between the GABA and control groups. DMT1(-IRE) expression was significantly reduced, but hephaestin expression was significantly increased in the GABA group compared with the control group. In addition, there was no significant difference in tyrosine hydroxylase expression between monosodium glutamate and GABA groups and the control group. These results suggested that glutamate affected iron metabolism in the caudate putamen by increasing DMT1(-IRE) and decreasing hephaestin expression. In addition, GABA decreased DMT1(-IRE) expression in the caudate putamen.关键词
glutamate/gamma-aminobutyric acid/tyrosine hydroxylase/divalent metal transporter 1 non iron response element/hephaestinKey words
glutamate/gamma-aminobutyric acid/tyrosine hydroxylase/divalent metal transporter 1 non iron response element/hephaestin分类
医药卫生引用本文复制引用
Na Wang,Peng Guan,Fei Li,Yujian Fu,Xianglin Duan,Yanzhong Chang..Sodium glutamate and gamma-aminobutyric acid affect iron metabolism in the rat caudate putamen[J].中国神经再生研究（英文版）,2010,5(21):1644-1649,6.基金项目
the National Natural Science Foundation of China,No.30570957 （）
the Natural Science Foundation of Hebei Province,No.C2006000152,C2007000251 （）
