首页|期刊导航|中国神经再生研究（英文版）|5-lipoxygenase expression in a brain damage model induced by chronic oral administration of aluminum
中国神经再生研究（英文版）2010，Vol.5Issue(21)：1634-1638,5.DOI:10.3969/j.issn.1673-5374.2010.21.006
5-lipoxygenase expression in a brain damage model induced by chronic oral administration of aluminum
5-lipoxygenase expression in a brain damage model induced by chronic oral administration of aluminum
摘要
Abstract
A preliminary study has found that the 5-lipoxygenase inhibitor, caffeic acid, has a marked protective effect on acute brain injury induced by intracerebroventricular microinjection of aluminum.In this experiment, chronic brain injury and neuronal degeneration model was established in rats by chronic oral administration of aluminum, and then intervened using caffeic acid. Results showed that caffeic acid can downregulate chronic aluminum overload-induced 5-lipoxygenase mRNA and protein expression, and repair the aluminum overload-induced hippocampal neuronal damage andspatial orientation impairment. It is suggested that direct intervention of 5-lipoxygenase expression has a neuroprotective role in the degeneration induced by chronic aluminum overload brain injury model.关键词
chronic aluminum overload/5-lipoxygenase/brain injury/caffeic acid/neural regenerationKey words
chronic aluminum overload/5-lipoxygenase/brain injury/caffeic acid/neural regeneration分类
医药卫生引用本文复制引用
Yongquan Pan,Peng Zhang,Junqing Yang,Qiang Su..5-lipoxygenase expression in a brain damage model induced by chronic oral administration of aluminum[J].中国神经再生研究（英文版）,2010,5(21):1634-1638,5.基金项目
the National Natural Science Foundation of China,No.30672211 （）
