首页|期刊导航|中国神经再生研究（英文版）|N-methyl-D-aspartate receptor expression in the spinal dorsal horn of a rat model of formalin-induced inflammatory pain following intrathecal injection of butorphanol
中国神经再生研究（英文版）2010，Vol.5Issue(21)：1617-1622,6.DOI:10.3969/j.issn.1673-5374.2010.21.003
N-methyl-D-aspartate receptor expression in the spinal dorsal horn of a rat model of formalin-induced inflammatory pain following intrathecal injection of butorphanol
N-methyl-D-aspartate receptor expression in the spinal dorsal horn of a rat model of formalin-induced inflammatory pain following intrathecal injection of butorphanol
摘要
Abstract
Clinical and animal experiments have proved that intrathecal injection of butorphanol has an analgesic effect. However, whether the analgesic effect is associated with activation of the N-methyl-D-aspartate (NMDA) receptor remains unclear. This study presumed that intrathecal injection of butorphanol has an analgesic effect on formalin-induced inflammatory pain in rats, and its analgesic effect is associated with inhibition of NMDA receptors. Concurrently, ketamine was injected into the intrathecal space, which is a non-competitive NMDA receptor antagonist, to determine the analgesic mechanism of butorphanol. The total reflection time in phase 1 and phase 2 of rat hind paws carding action was reduced when the butorphanol dose was increased to 25 μg,or a low dose of butorphanol was combined with ketamine. Intrathecal injection of a high dose of butorphanol alone or a Iow dose of butorphanol combined with ketamine can remarkably reduce NMDA receptor expression in the L5 spinal dorsal horn of formalin-induced pain rats. The results suggest that intrathecal injection of butorphanol has analgesic effects on formalin-induced inflammatory pain, and remarkably reduces NMDA receptor expression in the rat spinal dorsal horn.Ketamine strengthens this analgesic effect. The analgesic mechanism of intrathecal injection of butorphanol is associated with inhibition of NMDA receptor activation.关键词
formaldehyde/butorphanol/ketamine/spinal cord/receptors,N-Methyl-D-Aspartate/administration and dosage/antagonists and inhibitors/analgesiaKey words
formaldehyde/butorphanol/ketamine/spinal cord/receptors,N-Methyl-D-Aspartate/administration and dosage/antagonists and inhibitors/analgesia分类
医药卫生引用本文复制引用
Yichun Wang,Yuan Zhang,Qulian Guo,Xiaohong Liu,Mingde Wang,Hui Luo..N-methyl-D-aspartate receptor expression in the spinal dorsal horn of a rat model of formalin-induced inflammatory pain following intrathecal injection of butorphanol[J].中国神经再生研究（英文版）,2010,5(21):1617-1622,6.基金项目
a Grant from Department of Science and Technology of Hunan Province,No.2009SK3112 （）
a Grant from Department of Health of Hunan Province,No.C2008005 （）
