首页|期刊导航|中国神经再生研究（英文版）|Extract of ginkgo biloba EGb761 inhibits cell apoptosis following spinal cord injury
中国神经再生研究（英文版）2010，Vol.5Issue(22)：1745-1749,5.DOI:10.3969/j.issn.1673-5374.2010.22.011
Extract of ginkgo biloba EGb761 inhibits cell apoptosis following spinal cord injury
Extract of ginkgo biloba EGb761 inhibits cell apoptosis following spinal cord injury
摘要
Abstract
The neuroprotective effects of ginkgo biloba extract have been shown in rats following spinal cord injury (SCI). However, the precise protective mechanisms remain unclear. In the present study, low-acid water-soluble extract of ginkgo biloba EGb761 was used to treat rats with SCI. Xanthin oxidase, thiobarbituric acid, terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling assay, and immunohistochemistry were utilized to detect lipid peroxidation, neural cell apoptosis, and inducible nitric oxide synthase activity in rats with SCI. Results revealed significantly increased superoxide dismutase activity, decreased malondialdehyde content, apoptotic index, and inducible nitric oxide synthase expression in SCI rats following EGb761 treatment. Therefore, EGb761 suppressed lipid peroxidation following SCI, relieved neural cell apoptosis, inhibited inducible nitric oxide synthase expression, and ultimately exerted protective effects on SCI.关键词
ginkgo biloba/spinal cord injury/superoxide dismutase/apoptosis/nitric oxide synthase/traditional Chinese medicine/neural regenerationKey words
ginkgo biloba/spinal cord injury/superoxide dismutase/apoptosis/nitric oxide synthase/traditional Chinese medicine/neural regeneration分类
医药卫生引用本文复制引用
Jiejun Jiao,Jiannong Jiang,Bin Du,Yuan Mo,Ming Zhou,Hongquan Zhang..Extract of ginkgo biloba EGb761 inhibits cell apoptosis following spinal cord injury[J].中国神经再生研究（英文版）,2010,5(22):1745-1749,5.基金项目
the Science and Technology Promotion Project for Livelihood of the People of Yixing City in 2008, No. Yikeji[2008]56, Yi-caiqi[2008]33, Yifa-gaifu[2008]100 （）
