首页|期刊导航|中国神经再生研究（英文版）|Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model of Parkinson's disease
中国神经再生研究（英文版）2010，Vol.5Issue(22)：1701-1705,5.DOI:10.3969/j.issn.1673-5374.2010.22.003
Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model of Parkinson's disease
Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model of Parkinson's disease
摘要
Abstract
Extensive iron deposition has been observed in the midbrain substantia nigra (SN) of Parkinson's disease (PD) patients, but the mechanisms of iron deposition in the SN remain poorly understood. The present study investigated the relationship between dopaminergic neuronal damage, iron content changes, and divalent metal transporter 1 (DMT1) in the midbrain SN of PD rats to explore the relationship between time of iron deposition and DMT1 expression. Frozen midbrain SN sections from model rats were stained with Perls' iron. Results showed massive loss of tyrosine hydroxylase (TH)-positive cells in the SN and increased DMT1 expression in model group rats. No obvious iron deposition was observed in the SN during early stages after damage, but significant iron deposition was detected at 8 weeks post-injury. Results demonstrate that the loss of TH-positive cells in the SN appeared simultaneously with increased DMT1 expression. Extensive iron deposition occurred at 8 weeks post injury, which could be regarded as an early time window of iron deposition.关键词
Parkinson's disease/rotenone/iron/divalent metal transporter 1/animal models/neurodegenerative diseaseKey words
Parkinson's disease/rotenone/iron/divalent metal transporter 1/animal models/neurodegenerative disease分类
医药卫生引用本文复制引用
Yangwen Song,Xin Chen,Chun Li,Nan Zhang..Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model of Parkinson's disease[J].中国神经再生研究（英文版）,2010,5(22):1701-1705,5.基金项目
the Scientific Research Common Program of Beijing Municipal Com-mission of Education, No. KM200610025008 （）
