环境与职业医学2011，Vol.28Issue(1)：32-34,3.
大豆异黄酮对雄性子代大鼠P450scc、MIS、ERβ基因表达的影响
Effects of Soy Isoflavone on Gene Expression of P450scc, MIS and ERβ in Male Offspring Rats
摘要
Abstract
[ Objective ] To explore the effects of soy isoflavone ( SIF ) on offspring male rats reproductive system after pregnancy exposure. [ Methods ] 40 pregnant rats were divided into five groups randomly. Soy isoflavone was delivered to the pregnant rats by gavage( peanut oil worked as solution, was delivered to control group )during the period of E 13～E 19, with the doses of O( control group ), 25, 50, 150, 450mg/kg. On postnatal day 18, Fl male rats were sacrificed, testieular tissues were obtained, the expression of P450scc, MIS, ERβmRNA in testis were measured by real-time PCR. [ Results ] Compared with the control group,the expressions of ERβ( P＜O.01 )and P450scc( P＞O.05 )were deceased by exposed to different doses of SIF, but MIS expression increased( 150, 450 mg/kg SIF, P ＜ 0.01 ). [ Conclusion ] SIF could alter reproductive-related gene expressions in the offspring male rat testes, which could lead to certain adverse effects.关键词
异黄酮/大鼠/胆固醇侧链裂解酶/苗勒管抑制物/β-雌激素受体Key words
isoflavane/ rats/ P450scc/ MIS/ Erβ分类
医药卫生引用本文复制引用
孙合涛,纪海续,周远忠,范奇元..大豆异黄酮对雄性子代大鼠P450scc、MIS、ERβ基因表达的影响[J].环境与职业医学,2011,28(1):32-34,3.基金项目
遵义医学院院资金(编号:F-214) （编号:F-214）
