中华医学杂志（英文版）2009，Vol.122Issue(23)：2856-2860,5.DOI:10.3760/cma.j.issn.0366-6999.2009.23.010
Treatment of platinum-resistant recurrent ovarian cancer using a "predictive molecule targeted routine chemotherapy" system
Treatment of platinum-resistant recurrent ovarian cancer using a "predictive molecule targeted routine chemotherapy" system
ZHAO Xiao-dong 1WEI Feng-hua 1ZHANG Yi 1HE Shu-rong 2YANG Li2
作者信息
- 1. Department of Obstetrics and Gynecology Beijing Hospital, Beijing 100730, China
- 2. Department of Pathology Beijing Hospital, Beijing 100730, China
- 折叠
摘要
Abstract
Background Correct drug selection, the key to successful chemotherapy, is one of the most difficult clinical decisions for the treatment of platinum-resistant recurrent ovarian cancer worldwide. The exact procedures for choosing drugs are undefined, currently relying on clinical trials and personal experience, which often results in disappointing outcomes. Here, we propose a new drug selection method, the "predictive molecule targeted routine chemotherapy", to choose relatively sensitive routine drugs and avoid relatively resistant routine drugs based on the specific predictive molecule expression of the individual tumor tissue.Methods From January 2004 to June 2008,26 cases of platinum-resistant recurrent ovarian cancer were prospectively recruited. Their routine chemotherapy drug choice was based on the expression of 6 predictive molecules (including p53) as determined by immunohistochemistry (the predictive molecule targeted routine chemotherapy group). A further 18 cases of platinum-resistant recurrent ovarian cancer were treated by experience and formed the control group. The response rate and the overall survival were compared between the two groups.Results The response rate to second-line chemotherapy was 28% in the control group and 77% in the predictive molecule targeted routine chemotherapy group (P=0.002). The response rate to third-line chemotherapy was 14% in the control group and 33% in the predictive molecule targeted routine chemotherapy group (P=0.268). The median overall survival of the predictive molecule targeted routine chemotherapy group (88 weeks) was significantly longer than the median overall survival of the control group (56 weeks) (P=0.0315).Conclusion The predictive molecule targeted routine chemotherapy is a new effective protocol for choosing drugs when treating platinum-resistant recurrent ovarian cancer.关键词
ovarian neoplasms/recurrence/chemotherapy/predictive moleculeKey words
ovarian neoplasms/recurrence/chemotherapy/predictive molecule引用本文复制引用
ZHAO Xiao-dong,WEI Feng-hua,ZHANG Yi,HE Shu-rong,YANG Li..Treatment of platinum-resistant recurrent ovarian cancer using a "predictive molecule targeted routine chemotherapy" system[J].中华医学杂志（英文版）,2009,122(23):2856-2860,5.
